Adult Hip Dysplasia - Prevalence and Consequence
Vinge, Rebecka LU
(2025)
In Lund University, Faculty of Medicine Doctoral Dissertation Series
- Abstract
- Background: Adult hip dysplasia is one of the few potentially modifiable risk factors for hip osteoarthritis (OA). However, the prevalence of hip dysplasia and the strength of its association with OA are not fully
understood.
Aims and methods:
I. To determine the prevalence of hip dysplasia in a Swedish population and investigate whether the condition was mentioned in radiology reports. The center edge angle was measured, and the radiology reports were reviewed for 1870 individuals aged 20–70 years who had undergone an anteroposterior pelvic radiograph in Malmö, Sweden, between 2007–2008 and had no other hip pathology.
II. To explore the development of radiographic hip OA in individuals with unilateral hip dysplasia... (More) - Background: Adult hip dysplasia is one of the few potentially modifiable risk factors for hip osteoarthritis (OA). However, the prevalence of hip dysplasia and the strength of its association with OA are not fully
understood.
Aims and methods:
I. To determine the prevalence of hip dysplasia in a Swedish population and investigate whether the condition was mentioned in radiology reports. The center edge angle was measured, and the radiology reports were reviewed for 1870 individuals aged 20–70 years who had undergone an anteroposterior pelvic radiograph in Malmö, Sweden, between 2007–2008 and had no other hip pathology.
II. To explore the development of radiographic hip OA in individuals with unilateral hip dysplasia identified in Study I and compare OA outcomes between dysplastic and contralateral non-dysplastic hips. A longitudinal review of the radiographic records of 50 individuals with unilateral hip dysplasia and available follow-up imaging was conducted to assess OA incidence, time to detection of OA, and joint space width.
III. To examine the relationship between hip dysplasia and the risk of developing radiographic hip OA at several time points using different definitions of hip dysplasia based on lateral and/or anterior undercoverage. The association was explored at the 2-, 5-, 8- and 10-year follow-ups of the CHECK study, with between 1169 to 1262 included hips depending on the follow-up time point.
IV. To examine the long-term association between hip dysplasia and clinically relevant hip OA. The outcome was defined by an expert diagnosis incorporating both clinical and radiographic data from the 5- to 10-year follow-ups of the CHECK study, and the analysis included 468 hips.
Results and conclusions:
In our Swedish study population, 5.2% had hip dysplasia, with most cases overlooked by radiologists, emphasizing the need for increased awareness of the condition. We found no evidence that radiographic OA developed earlier or more frequently in dysplastic hips compared to contralateral non-dysplastic hips of individuals with unilateral hip dysplasia, suggesting similar radiographic monitoring for both. The strongest and most consistent associations with radiographic OA development were observed when both anterior and lateral projections were used to define hip dysplasia. The highest increased risk (2.5-fold) was found at the 2-year follow-up. All associations weakened over time and disappeared by the 10-year follow-up. These findings highlight the importance of early detection of hip dysplasia, and incorporation of anterior undercoverage assessment, to identify individuals at higher risk of radiographic OA development. Lastly, individuals with hip dysplasia were found to have a nearly three times increased risk of clinically relevant hip OA after 10 years of follow-up, underscoring the need for a clinically relevant definition of OA in future research on hip dysplasia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5ee9b21a-aba2-438f-b0a9-b8c43ed454fb
- author
- Vinge, Rebecka
LU
- supervisor
- opponent
-
- Professor Kim, Young-Jo, Harvard Medical School, Boston Children's Hospital, Boston, USA
- organization
- publishing date
- 2025
- type
- Thesis
- publication status
- published
- subject
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2025:63
- pages
- 76 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Segerfalksalen, BMC A10, Sölvegatan 17 i Lund. Join by Zoom: https://lu-se.zoom.us/j/64997004517
- defense date
- 2025-05-28 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-716-3
- language
- English
- LU publication?
- yes
- id
- 5ee9b21a-aba2-438f-b0a9-b8c43ed454fb
- date added to LUP
- 2025-04-24 11:03:04
- date last changed
- 2025-04-28 12:38:16
@phdthesis{5ee9b21a-aba2-438f-b0a9-b8c43ed454fb,
abstract = {{Background: Adult hip dysplasia is one of the few potentially modifiable risk factors for hip osteoarthritis (OA). However, the prevalence of hip dysplasia and the strength of its association with OA are not fully<br/>understood.<br/><br/>Aims and methods:<br/>I. To determine the prevalence of hip dysplasia in a Swedish population and investigate whether the condition was mentioned in radiology reports. The center edge angle was measured, and the radiology reports were reviewed for 1870 individuals aged 20–70 years who had undergone an anteroposterior pelvic radiograph in Malmö, Sweden, between 2007–2008 and had no other hip pathology.<br/>II. To explore the development of radiographic hip OA in individuals with unilateral hip dysplasia identified in Study I and compare OA outcomes between dysplastic and contralateral non-dysplastic hips. A longitudinal review of the radiographic records of 50 individuals with unilateral hip dysplasia and available follow-up imaging was conducted to assess OA incidence, time to detection of OA, and joint space width.<br/>III. To examine the relationship between hip dysplasia and the risk of developing radiographic hip OA at several time points using different definitions of hip dysplasia based on lateral and/or anterior undercoverage. The association was explored at the 2-, 5-, 8- and 10-year follow-ups of the CHECK study, with between 1169 to 1262 included hips depending on the follow-up time point.<br/>IV. To examine the long-term association between hip dysplasia and clinically relevant hip OA. The outcome was defined by an expert diagnosis incorporating both clinical and radiographic data from the 5- to 10-year follow-ups of the CHECK study, and the analysis included 468 hips.<br/><br/>Results and conclusions:<br/>In our Swedish study population, 5.2% had hip dysplasia, with most cases overlooked by radiologists, emphasizing the need for increased awareness of the condition. We found no evidence that radiographic OA developed earlier or more frequently in dysplastic hips compared to contralateral non-dysplastic hips of individuals with unilateral hip dysplasia, suggesting similar radiographic monitoring for both. The strongest and most consistent associations with radiographic OA development were observed when both anterior and lateral projections were used to define hip dysplasia. The highest increased risk (2.5-fold) was found at the 2-year follow-up. All associations weakened over time and disappeared by the 10-year follow-up. These findings highlight the importance of early detection of hip dysplasia, and incorporation of anterior undercoverage assessment, to identify individuals at higher risk of radiographic OA development. Lastly, individuals with hip dysplasia were found to have a nearly three times increased risk of clinically relevant hip OA after 10 years of follow-up, underscoring the need for a clinically relevant definition of OA in future research on hip dysplasia.}},
author = {{Vinge, Rebecka}},
isbn = {{978-91-8021-716-3}},
issn = {{1652-8220}},
language = {{eng}},
number = {{2025:63}},
publisher = {{Lund University, Faculty of Medicine}},
school = {{Lund University}},
series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
title = {{Adult Hip Dysplasia - Prevalence and Consequence}},
url = {{https://lup.lub.lu.se/search/files/217813459/Avhandling_Rebecka_Vinge_LUCRIS.pdf}},
year = {{2025}},
}