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Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).

Riedstra, N. S. ; Vinge, R. LU orcid ; Herfkens, J. ; Eygendaal, D. ; Bierma-Zeinstra, S. M.A. ; Runhaar, J. ; van Buuren, M. M.A. and Agricola, R. (2023) In Seminars in Arthritis and Rheumatism 60.
Abstract

Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL... (More)

Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations. Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00–6.04), 5 years follow-up (OR 2.28, 95% CI 1.20–4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22–2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02–13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up. Conclusion: Baseline AD in individuals between 45 and 65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental dysplasia, Diagnostic imaging, Epidemiology, Hip shape, Morphology, Risk factor
in
Seminars in Arthritis and Rheumatism
volume
60
article number
152194
publisher
W.B. Saunders
external identifiers
  • scopus:85151271113
  • pmid:37011579
ISSN
0049-0172
DOI
10.1016/j.semarthrit.2023.152194
language
English
LU publication?
yes
id
c8c87563-603a-4851-8493-d718c70ae7fc
date added to LUP
2023-05-15 15:10:58
date last changed
2024-06-15 02:55:51
@article{c8c87563-603a-4851-8493-d718c70ae7fc,
  abstract     = {{<p>Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both &lt;25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren &amp; Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations. Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00–6.04), 5 years follow-up (OR 2.28, 95% CI 1.20–4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22–2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02–13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up. Conclusion: Baseline AD in individuals between 45 and 65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.</p>}},
  author       = {{Riedstra, N. S. and Vinge, R. and Herfkens, J. and Eygendaal, D. and Bierma-Zeinstra, S. M.A. and Runhaar, J. and van Buuren, M. M.A. and Agricola, R.}},
  issn         = {{0049-0172}},
  keywords     = {{Developmental dysplasia; Diagnostic imaging; Epidemiology; Hip shape; Morphology; Risk factor}},
  language     = {{eng}},
  publisher    = {{W.B. Saunders}},
  series       = {{Seminars in Arthritis and Rheumatism}},
  title        = {{Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).}},
  url          = {{http://dx.doi.org/10.1016/j.semarthrit.2023.152194}},
  doi          = {{10.1016/j.semarthrit.2023.152194}},
  volume       = {{60}},
  year         = {{2023}},
}