Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).
(2023) In Seminars in Arthritis and Rheumatism 60.- Abstract
Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL... (More)
Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations. Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00–6.04), 5 years follow-up (OR 2.28, 95% CI 1.20–4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22–2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02–13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up. Conclusion: Baseline AD in individuals between 45 and 65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.
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- author
- Riedstra, N. S. ; Vinge, R. LU ; Herfkens, J. ; Eygendaal, D. ; Bierma-Zeinstra, S. M.A. ; Runhaar, J. ; van Buuren, M. M.A. and Agricola, R.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Developmental dysplasia, Diagnostic imaging, Epidemiology, Hip shape, Morphology, Risk factor
- in
- Seminars in Arthritis and Rheumatism
- volume
- 60
- article number
- 152194
- publisher
- W.B. Saunders
- external identifiers
-
- scopus:85151271113
- pmid:37011579
- ISSN
- 0049-0172
- DOI
- 10.1016/j.semarthrit.2023.152194
- language
- English
- LU publication?
- yes
- id
- c8c87563-603a-4851-8493-d718c70ae7fc
- date added to LUP
- 2023-05-15 15:10:58
- date last changed
- 2024-09-21 12:01:21
@article{c8c87563-603a-4851-8493-d718c70ae7fc, abstract = {{<p>Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations. Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00–6.04), 5 years follow-up (OR 2.28, 95% CI 1.20–4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22–2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02–13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up. Conclusion: Baseline AD in individuals between 45 and 65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.</p>}}, author = {{Riedstra, N. S. and Vinge, R. and Herfkens, J. and Eygendaal, D. and Bierma-Zeinstra, S. M.A. and Runhaar, J. and van Buuren, M. M.A. and Agricola, R.}}, issn = {{0049-0172}}, keywords = {{Developmental dysplasia; Diagnostic imaging; Epidemiology; Hip shape; Morphology; Risk factor}}, language = {{eng}}, publisher = {{W.B. Saunders}}, series = {{Seminars in Arthritis and Rheumatism}}, title = {{Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).}}, url = {{http://dx.doi.org/10.1016/j.semarthrit.2023.152194}}, doi = {{10.1016/j.semarthrit.2023.152194}}, volume = {{60}}, year = {{2023}}, }