Late cardiac events after childhood cancer : Methodological aspects of the pan-european study pancaresurfup
(2016) In PLoS ONE 11(9).- Abstract
Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data onsymptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events.... (More)
Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data onsymptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected. Results The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient-And general practitioner-based questionnaires. Conclusion The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platformfor future research studies in childhood cancer patients.
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- author
- organization
- publishing date
- 2016-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 9
- article number
- e0162778
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:27643694
- scopus:84992347151
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0162778
- language
- English
- LU publication?
- yes
- id
- 5f0e2914-003f-41d0-810c-35f733a7beb1
- date added to LUP
- 2016-11-16 15:15:34
- date last changed
- 2024-04-05 10:24:47
@article{5f0e2914-003f-41d0-810c-35f733a7beb1,
abstract = {{<p>Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data onsymptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected. Results The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient-And general practitioner-based questionnaires. Conclusion The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platformfor future research studies in childhood cancer patients.</p>}},
author = {{Feijen, Elizabeth A M and Font-Gonzalez, Anna and Van Dalen, Elvira C. and Van Der Pal, Helena J H and Reulen, Raoul C. and Winter, David L. and Kuehni, Claudia E. and Haupt, Riccardo and Alessi, Daniela and Byrne, Julianne and Bardi, Edit and Jakab, Zsuzsanna and Grabo, Desiree and Garwicz, Stanislaw and Jankovic, Momcilo and Levitt, Gill A. and Skinner, Roderick and Zaletel, Lorna Zadravec and Hjorth, Lars and Tissing, Wim J E and De Vathaire, Florent and Hawkins, Mike M. and Kremer, Leontien C M}},
issn = {{1932-6203}},
language = {{eng}},
month = {{09}},
number = {{9}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Late cardiac events after childhood cancer : Methodological aspects of the pan-european study pancaresurfup}},
url = {{http://dx.doi.org/10.1371/journal.pone.0162778}},
doi = {{10.1371/journal.pone.0162778}},
volume = {{11}},
year = {{2016}},
}