A prospective, controlled study on the utility of rotational thromboelastometry in surgery for acute type A aortic dissection
(2022) In Scientific Reports 12(1).- Abstract
To evaluate the hemostatic system with ROTEM in patients undergoing surgery for acute type aortic dissection (ATAAD) using elective aortic procedures as controls. This was a prospective, controlled, observational study. The study was performed at a tertiary referral center and university hospital. Twenty-three patients with ATAAD were compared to 20 control patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM (INTEM, EXTEM, HEPTEM and FIBTEM) was tested at 6 points in time before, during and after surgery for ATAAD or elective aortic surgery. The ATAAD group had an activated coagulation coming into the surgical theatre. The two groups showed activation of both major coagulation pathways during surgery,... (More)
To evaluate the hemostatic system with ROTEM in patients undergoing surgery for acute type aortic dissection (ATAAD) using elective aortic procedures as controls. This was a prospective, controlled, observational study. The study was performed at a tertiary referral center and university hospital. Twenty-three patients with ATAAD were compared to 20 control patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM (INTEM, EXTEM, HEPTEM and FIBTEM) was tested at 6 points in time before, during and after surgery for ATAAD or elective aortic surgery. The ATAAD group had an activated coagulation coming into the surgical theatre. The two groups showed activation of both major coagulation pathways during surgery, but the ATAAD group consistently had larger deficiencies. Reversal of the coagulopathy was successful, although none of the groups reached elective baseline until postoperative day 1. ROTEM did not detect low levels of clotting factors at heparin reversal nor low levels of platelets. This study demonstrated that ATAAD is associated with a coagulopathic state. Surgery causes additional damage to the hemostatic system in ATAAD patients as well as in patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM does not adequately catch the full coagulopathy in ATAAD. A transfusion protocol in ATAAD should be specifically created to target this complex coagulopathic state and ROTEM does not negate the need for routine laboratory tests.
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- author
- Larsson, Mårten LU ; Zindovic, Igor LU ; Sjögren, Johan LU ; Svensson, Peter J. LU ; Strandberg, Karin LU and Nozohoor, Shahab LU
- organization
-
- Bleeding disorders and acute typ-A dissection (research group)
- Minimal invasive cardiac surgery in valvular heart disease (research group)
- Neurological injury in acute type A aortic dissection (research group)
- Heparin bindning protein in cardiothoracic surgery (research group)
- Clinical Coagulation, Malmö (research group)
- EpiHealth: Epidemiology for Health
- publishing date
- 2022-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 12
- issue
- 1
- article number
- 18950
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:36347972
- scopus:85141351804
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-022-23701-z
- language
- English
- LU publication?
- yes
- id
- 5f50f0f5-dd8c-46d9-a4d3-a37ff413c515
- date added to LUP
- 2022-12-05 13:27:31
- date last changed
- 2024-04-18 15:51:42
@article{5f50f0f5-dd8c-46d9-a4d3-a37ff413c515, abstract = {{<p>To evaluate the hemostatic system with ROTEM in patients undergoing surgery for acute type aortic dissection (ATAAD) using elective aortic procedures as controls. This was a prospective, controlled, observational study. The study was performed at a tertiary referral center and university hospital. Twenty-three patients with ATAAD were compared to 20 control patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM (INTEM, EXTEM, HEPTEM and FIBTEM) was tested at 6 points in time before, during and after surgery for ATAAD or elective aortic surgery. The ATAAD group had an activated coagulation coming into the surgical theatre. The two groups showed activation of both major coagulation pathways during surgery, but the ATAAD group consistently had larger deficiencies. Reversal of the coagulopathy was successful, although none of the groups reached elective baseline until postoperative day 1. ROTEM did not detect low levels of clotting factors at heparin reversal nor low levels of platelets. This study demonstrated that ATAAD is associated with a coagulopathic state. Surgery causes additional damage to the hemostatic system in ATAAD patients as well as in patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM does not adequately catch the full coagulopathy in ATAAD. A transfusion protocol in ATAAD should be specifically created to target this complex coagulopathic state and ROTEM does not negate the need for routine laboratory tests.</p>}}, author = {{Larsson, Mårten and Zindovic, Igor and Sjögren, Johan and Svensson, Peter J. and Strandberg, Karin and Nozohoor, Shahab}}, issn = {{2045-2322}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{A prospective, controlled study on the utility of rotational thromboelastometry in surgery for acute type A aortic dissection}}, url = {{http://dx.doi.org/10.1038/s41598-022-23701-z}}, doi = {{10.1038/s41598-022-23701-z}}, volume = {{12}}, year = {{2022}}, }