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Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis : a cohort study

Hangaard, Stine; Gudbergsen, Henrik; Skougaard, Marie; Bliddal, Henning; Nybing, Janus D.; Tiderius, Carl Johan LU and Boesen, Mikael (2018) In Acta Radiologica 59(3). p.336-340
Abstract

Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no... (More)

Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) (P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% (P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion: Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cartilage, dGEMRIC, Knee osteoarthritis (KOA), magnetic resonance imaging (MRI), weight loss
in
Acta Radiologica
volume
59
issue
3
pages
5 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85041723263
ISSN
0284-1851
DOI
10.1177/0284185117720857
language
English
LU publication?
yes
id
5f727f8f-a2e7-47b7-a48c-ccb245ffbb15
date added to LUP
2018-03-01 09:38:32
date last changed
2018-05-29 11:12:02
@article{5f727f8f-a2e7-47b7-a48c-ccb245ffbb15,
  abstract     = {<p>Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) (P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% (P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion: Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.</p>},
  author       = {Hangaard, Stine and Gudbergsen, Henrik and Skougaard, Marie and Bliddal, Henning and Nybing, Janus D. and Tiderius, Carl Johan and Boesen, Mikael},
  issn         = {0284-1851},
  keyword      = {cartilage,dGEMRIC,Knee osteoarthritis (KOA),magnetic resonance imaging (MRI),weight loss},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {336--340},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis : a cohort study},
  url          = {http://dx.doi.org/10.1177/0284185117720857},
  volume       = {59},
  year         = {2018},
}