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A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.

Veitonmäki, Niina; Hansson, Markus LU ; Zhan, Fenghuang; Sundberg, Annika; Löfstedt, Tobias LU ; Ljungars, Anne; Li, Zhan-Chun; Martinsson-Niskanen, Titti; Zeng, Ming and Yang, Ye, et al. (2013) In Cancer Cell 23(4). p.502-515
Abstract
We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering "function-first" approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to... (More)
We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering "function-first" approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma. (Less)
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type
Contribution to journal
publication status
published
subject
in
Cancer Cell
volume
23
issue
4
pages
502 - 515
publisher
Cell Press
external identifiers
  • wos:000317943900010
  • pmid:23597564
  • scopus:84876385896
ISSN
1878-3686
DOI
10.1016/j.ccr.2013.02.026
language
English
LU publication?
yes
id
5f8f17c9-2f57-44fa-9d32-096b5e674101 (old id 3733600)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23597564?dopt=Abstract
date added to LUP
2013-05-04 19:43:40
date last changed
2019-04-30 01:28:12
@article{5f8f17c9-2f57-44fa-9d32-096b5e674101,
  abstract     = {We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering "function-first" approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma.},
  author       = {Veitonmäki, Niina and Hansson, Markus and Zhan, Fenghuang and Sundberg, Annika and Löfstedt, Tobias and Ljungars, Anne and Li, Zhan-Chun and Martinsson-Niskanen, Titti and Zeng, Ming and Yang, Ye and Danielsson, Lena and Kovacek, Mathilda and Lundqvist, Andrea and Mårtensson, Linda and Teige, Ingrid and Tricot, Guido and Frendéus, Björn},
  issn         = {1878-3686},
  language     = {eng},
  number       = {4},
  pages        = {502--515},
  publisher    = {Cell Press},
  series       = {Cancer Cell},
  title        = {A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.},
  url          = {http://dx.doi.org/10.1016/j.ccr.2013.02.026},
  volume       = {23},
  year         = {2013},
}