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Soluble CD163 was linked to galectin-3, diabetic retinopathy and antidepressants in type 1 diabetes

Melin, Eva O LU ; Dereke, Jonatan LU ; Thunander, Maria LU and Hillman, Magnus LU (2018) In Endocrine Connections 7(12). p.1343-1353
Abstract

OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.

DESIGN: Cross sectional.

METHODS: Two hundred and eighty-seven T1D patients, men 56%,... (More)

OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.

DESIGN: Cross sectional.

METHODS: Two hundred and eighty-seven T1D patients, men 56%, age 18-59 years, diabetes duration ≥1 year, were consecutively recruited from one specialist diabetes clinic. Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from electronic medical records and the Swedish National Diabetes Registry. High plasma sCD163 was defined as ≥ 0.575 mg/l (corresponding to the 80th percentile) and high plasma galectin-3 as ≥4.659 µg/l (corresponding to the 95th percentile).

RESULTS: The prevalence of depression was 10%, antidepressant medication 8%, diabetic retinopathy 72%, high sCD163 20%, and high galectin-3 5%. High galectin-3 (AOR 9.7), antidepressants (AOR 3.8), diabetic retinopathy (AOR 2.4), and systolic blood pressure (per mm Hg) (AOR 1.03) were associated with high sCD163.

CONCLUSIONS: This is the first study to show that circulating sCD163 was independently associated with galectin-3, the use of antidepressants, and diabetic retinopathy, in patients with T1D. Depression was not associated with sCD163.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Endocrine Connections
volume
7
issue
12
pages
1343 - 1353
publisher
BioScientifica Ltd.
ISSN
2049-3614
DOI
10.1530/EC-18-0336
language
English
LU publication?
yes
id
5f9abfca-f7ba-4988-b9f6-b852d6746566
date added to LUP
2019-01-10 14:43:59
date last changed
2019-01-11 14:33:29
@article{5f9abfca-f7ba-4988-b9f6-b852d6746566,
  abstract     = {<p>OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.</p><p>DESIGN: Cross sectional.</p><p>METHODS: Two hundred and eighty-seven T1D patients, men 56%, age 18-59 years, diabetes duration ≥1 year, were consecutively recruited from one specialist diabetes clinic. Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from electronic medical records and the Swedish National Diabetes Registry. High plasma sCD163 was defined as ≥ 0.575 mg/l (corresponding to the 80th percentile) and high plasma galectin-3 as ≥4.659 µg/l (corresponding to the 95th percentile).</p><p>RESULTS: The prevalence of depression was 10%, antidepressant medication 8%, diabetic retinopathy 72%, high sCD163 20%, and high galectin-3 5%. High galectin-3 (AOR 9.7), antidepressants (AOR 3.8), diabetic retinopathy (AOR 2.4), and systolic blood pressure (per mm Hg) (AOR 1.03) were associated with high sCD163.</p><p>CONCLUSIONS: This is the first study to show that circulating sCD163 was independently associated with galectin-3, the use of antidepressants, and diabetic retinopathy, in patients with T1D. Depression was not associated with sCD163.</p>},
  author       = {Melin, Eva O and Dereke, Jonatan and Thunander, Maria and Hillman, Magnus},
  issn         = {2049-3614},
  language     = {eng},
  number       = {12},
  pages        = {1343--1353},
  publisher    = {BioScientifica Ltd.},
  series       = {Endocrine Connections},
  title        = {Soluble CD163 was linked to galectin-3, diabetic retinopathy and antidepressants in type 1 diabetes},
  url          = {http://dx.doi.org/10.1530/EC-18-0336},
  volume       = {7},
  year         = {2018},
}