Elevations in blood glucose before and after the appearance of islet autoantibodies in children
(2022) In Journal of Clinical Investigation 132(20).- Abstract
The etiology of type 1 diabetes has polygenic and environmental determinants that lead to autoimmune responses against pancreatic β cells and promote β cell death. The autoimmunity is considered silent without metabolic consequences until late preclinical stages,and it remains unknown how early in the disease process the pancreatic β cell is compromised. To address this, we investigated preprandial nonfasting and postprandial blood glucose concentrations and islet autoantibody development in 1,050 children with high genetic risk of type 1 diabetes. Pre-And postprandial blood glucose decreased between 4 and 18 months of age and gradually increased until the final measurements at 3.6 years of age. Determinants of blood glucose... (More)
The etiology of type 1 diabetes has polygenic and environmental determinants that lead to autoimmune responses against pancreatic β cells and promote β cell death. The autoimmunity is considered silent without metabolic consequences until late preclinical stages,and it remains unknown how early in the disease process the pancreatic β cell is compromised. To address this, we investigated preprandial nonfasting and postprandial blood glucose concentrations and islet autoantibody development in 1,050 children with high genetic risk of type 1 diabetes. Pre-And postprandial blood glucose decreased between 4 and 18 months of age and gradually increased until the final measurements at 3.6 years of age. Determinants of blood glucose trajectories in the first year of life included sex, body mass index, glucose-related genetic risk scores, and the type 1 diabetes-susceptible INS gene. Children who developed islet autoantibodies had early elevations in blood glucose concentrations. A sharp and sustained rise in postprandial blood glucose was observed at around 2 months prior to autoantibody seroconversion, with further increases in postprandial and, subsequently, preprandial values after seroconversion. These findings show heterogeneity in blood glucose control in infancy and early childhood and suggest that islet autoimmunity is concurrent or subsequent to insults on the pancreatic islets.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Investigation
- volume
- 132
- issue
- 20
- article number
- e162123
- publisher
- The American Society for Clinical Investigation
- external identifiers
-
- scopus:85139887851
- pmid:36250461
- ISSN
- 0021-9738
- DOI
- 10.1172/JCI162123
- language
- English
- LU publication?
- yes
- id
- 5f9ba6af-52a5-4ce2-a3e6-e00dfa2bf172
- date added to LUP
- 2022-12-13 12:48:39
- date last changed
- 2024-06-15 00:15:33
@article{5f9ba6af-52a5-4ce2-a3e6-e00dfa2bf172,
abstract = {{<p>The etiology of type 1 diabetes has polygenic and environmental determinants that lead to autoimmune responses against pancreatic β cells and promote β cell death. The autoimmunity is considered silent without metabolic consequences until late preclinical stages,and it remains unknown how early in the disease process the pancreatic β cell is compromised. To address this, we investigated preprandial nonfasting and postprandial blood glucose concentrations and islet autoantibody development in 1,050 children with high genetic risk of type 1 diabetes. Pre-And postprandial blood glucose decreased between 4 and 18 months of age and gradually increased until the final measurements at 3.6 years of age. Determinants of blood glucose trajectories in the first year of life included sex, body mass index, glucose-related genetic risk scores, and the type 1 diabetes-susceptible INS gene. Children who developed islet autoantibodies had early elevations in blood glucose concentrations. A sharp and sustained rise in postprandial blood glucose was observed at around 2 months prior to autoantibody seroconversion, with further increases in postprandial and, subsequently, preprandial values after seroconversion. These findings show heterogeneity in blood glucose control in infancy and early childhood and suggest that islet autoimmunity is concurrent or subsequent to insults on the pancreatic islets.</p>}},
author = {{Warncke, Katharina and Weiss, Andreas and Achenbach, Peter and Von Dem Berge, Thekla and Berner, Reinhard and Casteels, Kristina and Groele, Lidia and Hatzikotoulas, Konstantinos and Hommel, Angela and Kordonouri, Olga and Larsson, Helena Elding and Lundgren, Markus and Marcus, Benjamin A. and Snape, Matthew D. and Szypowska, Agnieszka and Todd, John A. and Bonifacio, Ezio and Ziegler, Anette G.}},
issn = {{0021-9738}},
language = {{eng}},
number = {{20}},
publisher = {{The American Society for Clinical Investigation}},
series = {{Journal of Clinical Investigation}},
title = {{Elevations in blood glucose before and after the appearance of islet autoantibodies in children}},
url = {{http://dx.doi.org/10.1172/JCI162123}},
doi = {{10.1172/JCI162123}},
volume = {{132}},
year = {{2022}},
}