Nonparametric 5D D-R2 distribution imaging with single-shot EPI at 21.1 T : Initial results for in vivo rat brain
(2022) In Journal of Magnetic Resonance 341.- Abstract
In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B0 and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural... (More)
In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B0 and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information.
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- author
- Rosenberg, Jens T. ; Grant, Samuel C. and Topgaard, Daniel LU
- organization
- publishing date
- 2022-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 21.1 T, Diffusion-relaxation correlation, In vivo, Multidimensional diffusion encoding, Nonparametric 5D D-R, Ultra-high field
- in
- Journal of Magnetic Resonance
- volume
- 341
- article number
- 107256
- publisher
- Academic Press
- external identifiers
-
- scopus:85132725184
- pmid:35753184
- ISSN
- 1090-7807
- DOI
- 10.1016/j.jmr.2022.107256
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022 Elsevier Inc.
- id
- 5fb9a079-7933-4b2a-8b13-b2bda698d9c6
- date added to LUP
- 2022-09-02 09:34:41
- date last changed
- 2024-04-03 11:45:30
@article{5fb9a079-7933-4b2a-8b13-b2bda698d9c6, abstract = {{<p>In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B<sub>0</sub> to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B<sub>0</sub> and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information.</p>}}, author = {{Rosenberg, Jens T. and Grant, Samuel C. and Topgaard, Daniel}}, issn = {{1090-7807}}, keywords = {{21.1 T; Diffusion-relaxation correlation; In vivo; Multidimensional diffusion encoding; Nonparametric 5D D-R; Ultra-high field}}, language = {{eng}}, month = {{08}}, publisher = {{Academic Press}}, series = {{Journal of Magnetic Resonance}}, title = {{Nonparametric 5D D-R<sub>2</sub> distribution imaging with single-shot EPI at 21.1 T : Initial results for in vivo rat brain}}, url = {{http://dx.doi.org/10.1016/j.jmr.2022.107256}}, doi = {{10.1016/j.jmr.2022.107256}}, volume = {{341}}, year = {{2022}}, }