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Nonparametric 5D D-R2 distribution imaging with single-shot EPI at 21.1 T : Initial results for in vivo rat brain

Rosenberg, Jens T. ; Grant, Samuel C. and Topgaard, Daniel LU (2022) In Journal of Magnetic Resonance 341.
Abstract

In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B0 and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural... (More)

In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B0 and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
21.1 T, Diffusion-relaxation correlation, In vivo, Multidimensional diffusion encoding, Nonparametric 5D D-R, Ultra-high field
in
Journal of Magnetic Resonance
volume
341
article number
107256
publisher
Academic Press
external identifiers
  • scopus:85132725184
  • pmid:35753184
ISSN
1090-7807
DOI
10.1016/j.jmr.2022.107256
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022 Elsevier Inc.
id
5fb9a079-7933-4b2a-8b13-b2bda698d9c6
date added to LUP
2022-09-02 09:34:41
date last changed
2024-04-03 11:45:30
@article{5fb9a079-7933-4b2a-8b13-b2bda698d9c6,
  abstract     = {{<p>In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B<sub>0</sub> to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B<sub>0</sub> and echo times with advanced encoding. Here, initial attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information.</p>}},
  author       = {{Rosenberg, Jens T. and Grant, Samuel C. and Topgaard, Daniel}},
  issn         = {{1090-7807}},
  keywords     = {{21.1 T; Diffusion-relaxation correlation; In vivo; Multidimensional diffusion encoding; Nonparametric 5D D-R; Ultra-high field}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Academic Press}},
  series       = {{Journal of Magnetic Resonance}},
  title        = {{Nonparametric 5D D-R<sub>2</sub> distribution imaging with single-shot EPI at 21.1 T : Initial results for in vivo rat brain}},
  url          = {{http://dx.doi.org/10.1016/j.jmr.2022.107256}},
  doi          = {{10.1016/j.jmr.2022.107256}},
  volume       = {{341}},
  year         = {{2022}},
}