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Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells

Lindstedt, Malin LU ; Johansson Lindbom, Bengt LU and Borrebaeck, Carl LU (2003) In Scandinavian Journal of Immunology 57(4). p.305-310
Abstract
Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, FDCs also provide potent nonspecific accessory signals to the B cells, which are important for the GC reaction. In this report, we show that human tonsilar FDCs express the costimulatory molecule CD137. Surface expression of CD137 on FDCs was confirmed by immunofluorescent labelling and fluorescence-activated cell sorter analysis. CD137 was also... (More)
Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, FDCs also provide potent nonspecific accessory signals to the B cells, which are important for the GC reaction. In this report, we show that human tonsilar FDCs express the costimulatory molecule CD137. Surface expression of CD137 on FDCs was confirmed by immunofluorescent labelling and fluorescence-activated cell sorter analysis. CD137 was also highly expressed by the human cell line HK, which displays many characteristics of in vivo FDCs. The interaction between B cells and FDCs is essential for the GC reactions, and our finding suggests that CD137 plays a role in FDC-regulated B-cell responses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Immunology
volume
57
issue
4
pages
305 - 310
publisher
Wiley-Blackwell
external identifiers
  • PMID:12662292
  • WOS:000181862300001
  • Scopus:0037385572
ISSN
1365-3083
DOI
10.1046/j.1365-3083.2003.01217.x
language
English
LU publication?
yes
id
95913de0-0f69-4935-889f-be58e6b06c8d (old id 603659)
date added to LUP
2007-11-28 13:21:48
date last changed
2017-01-01 07:46:01
@article{95913de0-0f69-4935-889f-be58e6b06c8d,
  abstract     = {Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, FDCs also provide potent nonspecific accessory signals to the B cells, which are important for the GC reaction. In this report, we show that human tonsilar FDCs express the costimulatory molecule CD137. Surface expression of CD137 on FDCs was confirmed by immunofluorescent labelling and fluorescence-activated cell sorter analysis. CD137 was also highly expressed by the human cell line HK, which displays many characteristics of in vivo FDCs. The interaction between B cells and FDCs is essential for the GC reactions, and our finding suggests that CD137 plays a role in FDC-regulated B-cell responses.},
  author       = {Lindstedt, Malin and Johansson Lindbom, Bengt and Borrebaeck, Carl},
  issn         = {1365-3083},
  language     = {eng},
  number       = {4},
  pages        = {305--310},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Immunology},
  title        = {Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells},
  url          = {http://dx.doi.org/10.1046/j.1365-3083.2003.01217.x},
  volume       = {57},
  year         = {2003},
}