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Higher plasma IL-6 and PTX3 are associated with worse survival in left heart failure with pulmonary hypertension

Helleberg, Sara ; Engel, Adam ; Ahmed, Salaheldin LU orcid ; Ahmed, Abdulla LU orcid and Rådegran, Göran LU (2022) In American Heart Journal Plus: Cardiology Research and Practice 20.
Abstract

Introduction: Left heart failure (LHF) is commonly complicated by pulmonary hypertension (PH), increasing morbidity and mortality. The present study aimed to evaluate the prognostic value of inflammatory proteins in LHF with PH (LHF-PH). Materials and methods: The levels of 65 plasma proteins, analysed with proximity extension assay, were compared between healthy controls (n = 20), patients with LHF-PH (n = 67) comprising both HFpEF-PH (n = 31) and HFrEF-PH (n = 36), and in a LHF subpopulation before and after heart transplantation (HT, n = 19). Haemodynamic parameters were measured using right heart catheterization. Results: Plasma levels of Interleukin 6 (IL-6) and Pentraxin related protein PTX3 (PTX3) were elevated in LHF-PH vs.... (More)

Introduction: Left heart failure (LHF) is commonly complicated by pulmonary hypertension (PH), increasing morbidity and mortality. The present study aimed to evaluate the prognostic value of inflammatory proteins in LHF with PH (LHF-PH). Materials and methods: The levels of 65 plasma proteins, analysed with proximity extension assay, were compared between healthy controls (n = 20), patients with LHF-PH (n = 67) comprising both HFpEF-PH (n = 31) and HFrEF-PH (n = 36), and in a LHF subpopulation before and after heart transplantation (HT, n = 19). Haemodynamic parameters were measured using right heart catheterization. Results: Plasma levels of Interleukin 6 (IL-6) and Pentraxin related protein PTX3 (PTX3) were elevated in LHF-PH vs. controls (p < 0.001), and these decreased after HT compared to before HT (p < 0.001). Plasma IL-6 and PTX3 correlated to elevated NT-proBNP (r = 0.44, p = 0.0002 and r = 0.4, p = 0.0009, respectively). Additionally, IL-6 correlated with mean pulmonary arterial pressure (r = 0.4, p = 0.0009) and mean right atrial pressure (r = 0.51, p < 0.0001). Higher levels of IL-6 and PTX3 were associated with worse survival rates in patients with LHF-PH (Log rank p < 0.01). Discussion: In patients with LHF-PH, higher plasma levels of IL-6 and PTX3 were associated with worse survival rates. Future larger studies to validate and investigate the direct clinical applicability of IL-6 and PTX3 as potential prognostic biomarkers are encouraged.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Haemodynamics, Heart transplantation, Inflammation, Interleukin 6, Left heart disease, Pentraxin related protein 3
in
American Heart Journal Plus: Cardiology Research and Practice
volume
20
article number
100190
external identifiers
  • scopus:85153895360
ISSN
2666-6022
DOI
10.1016/j.ahjo.2022.100190
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022
id
603c4759-0ac0-4b7e-9a6f-3d5b3540e239
date added to LUP
2023-06-05 21:56:23
date last changed
2023-06-07 15:57:22
@article{603c4759-0ac0-4b7e-9a6f-3d5b3540e239,
  abstract     = {{<p>Introduction: Left heart failure (LHF) is commonly complicated by pulmonary hypertension (PH), increasing morbidity and mortality. The present study aimed to evaluate the prognostic value of inflammatory proteins in LHF with PH (LHF-PH). Materials and methods: The levels of 65 plasma proteins, analysed with proximity extension assay, were compared between healthy controls (n = 20), patients with LHF-PH (n = 67) comprising both HFpEF-PH (n = 31) and HFrEF-PH (n = 36), and in a LHF subpopulation before and after heart transplantation (HT, n = 19). Haemodynamic parameters were measured using right heart catheterization. Results: Plasma levels of Interleukin 6 (IL-6) and Pentraxin related protein PTX3 (PTX3) were elevated in LHF-PH vs. controls (p &lt; 0.001), and these decreased after HT compared to before HT (p &lt; 0.001). Plasma IL-6 and PTX3 correlated to elevated NT-proBNP (r = 0.44, p = 0.0002 and r = 0.4, p = 0.0009, respectively). Additionally, IL-6 correlated with mean pulmonary arterial pressure (r = 0.4, p = 0.0009) and mean right atrial pressure (r = 0.51, p &lt; 0.0001). Higher levels of IL-6 and PTX3 were associated with worse survival rates in patients with LHF-PH (Log rank p &lt; 0.01). Discussion: In patients with LHF-PH, higher plasma levels of IL-6 and PTX3 were associated with worse survival rates. Future larger studies to validate and investigate the direct clinical applicability of IL-6 and PTX3 as potential prognostic biomarkers are encouraged.</p>}},
  author       = {{Helleberg, Sara and Engel, Adam and Ahmed, Salaheldin and Ahmed, Abdulla and Rådegran, Göran}},
  issn         = {{2666-6022}},
  keywords     = {{Biomarkers; Haemodynamics; Heart transplantation; Inflammation; Interleukin 6; Left heart disease; Pentraxin related protein 3}},
  language     = {{eng}},
  series       = {{American Heart Journal Plus: Cardiology Research and Practice}},
  title        = {{Higher plasma IL-6 and PTX3 are associated with worse survival in left heart failure with pulmonary hypertension}},
  url          = {{http://dx.doi.org/10.1016/j.ahjo.2022.100190}},
  doi          = {{10.1016/j.ahjo.2022.100190}},
  volume       = {{20}},
  year         = {{2022}},
}