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Neurotransmitter candidates in the vomeronasal organ of the rat.

Uddman, Rolf LU ; Malm, Lars LU and Cardell, Lars-Olaf LU (2007) In Acta Oto-Laryngologica 127(9). p.952-956
Abstract
Conclusion: The rich supply of nerve fibres containing neurotransmitters, particularly those containing SP and CGRP, is suggested to be a prerequisite for the recognition of chemical irritants as part of a chemical sense. Objective: The present study was designed to examine the distribution of different neurotransmitter candidates in the vomeronasal organ (VNO) of rats. Materials and methods: The distribution of neurotransmitter candidates was studied in the vomeronasal organ of the rat using immunocytochemistry. Results: The neuronal marker protein gene product 9.5 revealed a very rich supply of nerve fibres within and beneath the sensory epithelium, around blood vessels and glands. A moderate supply of nerve fibres containing tyrosine... (More)
Conclusion: The rich supply of nerve fibres containing neurotransmitters, particularly those containing SP and CGRP, is suggested to be a prerequisite for the recognition of chemical irritants as part of a chemical sense. Objective: The present study was designed to examine the distribution of different neurotransmitter candidates in the vomeronasal organ (VNO) of rats. Materials and methods: The distribution of neurotransmitter candidates was studied in the vomeronasal organ of the rat using immunocytochemistry. Results: The neuronal marker protein gene product 9.5 revealed a very rich supply of nerve fibres within and beneath the sensory epithelium, around blood vessels and glands. A moderate supply of nerve fibres containing tyrosine hydroxylase and neuropeptide Y was mostly seen close to blood vessels. Numerous nerve fibres containing nitric oxide synthase and vasoactive intestinal peptide were seen around blood vessels and in the subepithelial layer, with occasional fibres within the epithelium. Only few fibres located in the subepithelial layer contained pituitary adenylate cyclase activating peptide. Nerve fibres containing substance P and in particular calcitonin gene-related peptide were abundant in and beneath the epithelium and scattered in the submucosal layers around blood vessels. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunocytochemistry, rat, neuropeptides, vomeronasal organ, accessory olfactory system
in
Acta Oto-Laryngologica
volume
127
issue
9
pages
952 - 956
publisher
Taylor & Francis
external identifiers
  • wos:000248942100010
  • scopus:34548329732
ISSN
1651-2251
DOI
10.1080/00016480601110220
language
English
LU publication?
yes
id
8ab5bc95-d618-45ad-9eae-5f6ba9726561 (old id 606697)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17712675&dopt=Abstract
date added to LUP
2008-01-03 11:31:07
date last changed
2017-01-01 06:48:26
@article{8ab5bc95-d618-45ad-9eae-5f6ba9726561,
  abstract     = {Conclusion: The rich supply of nerve fibres containing neurotransmitters, particularly those containing SP and CGRP, is suggested to be a prerequisite for the recognition of chemical irritants as part of a chemical sense. Objective: The present study was designed to examine the distribution of different neurotransmitter candidates in the vomeronasal organ (VNO) of rats. Materials and methods: The distribution of neurotransmitter candidates was studied in the vomeronasal organ of the rat using immunocytochemistry. Results: The neuronal marker protein gene product 9.5 revealed a very rich supply of nerve fibres within and beneath the sensory epithelium, around blood vessels and glands. A moderate supply of nerve fibres containing tyrosine hydroxylase and neuropeptide Y was mostly seen close to blood vessels. Numerous nerve fibres containing nitric oxide synthase and vasoactive intestinal peptide were seen around blood vessels and in the subepithelial layer, with occasional fibres within the epithelium. Only few fibres located in the subepithelial layer contained pituitary adenylate cyclase activating peptide. Nerve fibres containing substance P and in particular calcitonin gene-related peptide were abundant in and beneath the epithelium and scattered in the submucosal layers around blood vessels.},
  author       = {Uddman, Rolf and Malm, Lars and Cardell, Lars-Olaf},
  issn         = {1651-2251},
  keyword      = {immunocytochemistry,rat,neuropeptides,vomeronasal organ,accessory olfactory system},
  language     = {eng},
  number       = {9},
  pages        = {952--956},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Neurotransmitter candidates in the vomeronasal organ of the rat.},
  url          = {http://dx.doi.org/10.1080/00016480601110220},
  volume       = {127},
  year         = {2007},
}