Plasma concentrations of apolipoproteins A-I, B, and M in patients with abdominal aortic aneurysms.
(2010) In Clinical Biochemistry 43(4-5). p.407-410- Abstract
- Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95%... (More)
- Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. Conclusions: ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511632
- author
- Ahnström, Josefin LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AAA, ApoA-I, ApoB, Aneurysmal disease, Lipocalin, Lipoprotein, Apolipoprotein, HDL, ApoM, Signal peptide
- in
- Clinical Biochemistry
- volume
- 43
- issue
- 4-5
- pages
- 407 - 410
- publisher
- Elsevier
- external identifiers
-
- wos:000275219400009
- pmid:19932694
- scopus:76749120943
- pmid:19932694
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2009.11.006
- language
- English
- LU publication?
- yes
- id
- 60690386-9793-4c49-b69a-738021488440 (old id 1511632)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19932694?dopt=Abstract
- date added to LUP
- 2016-04-01 09:55:10
- date last changed
- 2022-04-27 08:52:12
@article{60690386-9793-4c49-b69a-738021488440, abstract = {{Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. Conclusions: ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA.}}, author = {{Ahnström, Josefin and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn}}, issn = {{1873-2933}}, keywords = {{AAA; ApoA-I; ApoB; Aneurysmal disease; Lipocalin; Lipoprotein; Apolipoprotein; HDL; ApoM; Signal peptide}}, language = {{eng}}, number = {{4-5}}, pages = {{407--410}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{Plasma concentrations of apolipoproteins A-I, B, and M in patients with abdominal aortic aneurysms.}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2009.11.006}}, doi = {{10.1016/j.clinbiochem.2009.11.006}}, volume = {{43}}, year = {{2010}}, }