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The risk associated with indwelling catheters in children with haemophilia.

Ljung, Rolf LU (2007) In British Journal of Haematology 138(5). p.580-586
Abstract
Infections are the most frequent complications associated with the use of central venous lines (CVLs) in children with haemophilia. Several retrospective studies that include data from a substantial number of patients have reported approximately 0.2-0.3 infections per 1000 catheter-days (mainly Port-A-Cath). Some studies have shown a much higher frequency of infections, 1-2/1000 catheter-days. The most plausible explanations, for the difference seen in frequency of infections with Port-A-Caths, are probably related to the protocol used for the device care and the quality of education and the compliance of the users, whether these are parents or health-care professionals. The figures are low for clinically apparent thrombosis in the larger... (More)
Infections are the most frequent complications associated with the use of central venous lines (CVLs) in children with haemophilia. Several retrospective studies that include data from a substantial number of patients have reported approximately 0.2-0.3 infections per 1000 catheter-days (mainly Port-A-Cath). Some studies have shown a much higher frequency of infections, 1-2/1000 catheter-days. The most plausible explanations, for the difference seen in frequency of infections with Port-A-Caths, are probably related to the protocol used for the device care and the quality of education and the compliance of the users, whether these are parents or health-care professionals. The figures are low for clinically apparent thrombosis in the larger series on record, but routine venograms were not performed in most of these series. In studies, where this has been performed, a high frequency of abnormalities (> 50%) on venograms have been seen in some series but not in others. Despite obvious potential risks with CVLs, they are useful in many cases and facilitate the treatment of a serious disorder. With careful guidelines and surveillance protocols, the risk of complications should be reduced in the future. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
actor VIII, factor IX, haemophilia A, haemophilia B, venous access
in
British Journal of Haematology
volume
138
issue
5
pages
580 - 586
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000248591100002
  • scopus:34547631468
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2007.06703.x
language
English
LU publication?
yes
id
b93b46e8-2c84-45cf-938e-37426e6ed3b0 (old id 606999)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17686052&dopt=Abstract
date added to LUP
2007-12-17 09:58:00
date last changed
2017-07-30 03:52:52
@article{b93b46e8-2c84-45cf-938e-37426e6ed3b0,
  abstract     = {Infections are the most frequent complications associated with the use of central venous lines (CVLs) in children with haemophilia. Several retrospective studies that include data from a substantial number of patients have reported approximately 0.2-0.3 infections per 1000 catheter-days (mainly Port-A-Cath). Some studies have shown a much higher frequency of infections, 1-2/1000 catheter-days. The most plausible explanations, for the difference seen in frequency of infections with Port-A-Caths, are probably related to the protocol used for the device care and the quality of education and the compliance of the users, whether these are parents or health-care professionals. The figures are low for clinically apparent thrombosis in the larger series on record, but routine venograms were not performed in most of these series. In studies, where this has been performed, a high frequency of abnormalities (> 50%) on venograms have been seen in some series but not in others. Despite obvious potential risks with CVLs, they are useful in many cases and facilitate the treatment of a serious disorder. With careful guidelines and surveillance protocols, the risk of complications should be reduced in the future.},
  author       = {Ljung, Rolf},
  issn         = {0007-1048},
  keyword      = {actor VIII,factor IX,haemophilia A,haemophilia B,venous access},
  language     = {eng},
  number       = {5},
  pages        = {580--586},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {The risk associated with indwelling catheters in children with haemophilia.},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2007.06703.x},
  volume       = {138},
  year         = {2007},
}