Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.
(2007) In Molecular Microbiology 65(5). p.1147-1157- Abstract
- Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet... (More)
- Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet aggregation and the generation of platelet-rich thrombi. Neutrophils and monocytes are in turn activated by the platelets. Platelet thrombi are deposited in the microvasculature, and aggregated platelets, IgG and M1 protein colocalize in biopsies from patients diagnosed with S. pyogenes toxic shock syndrome. This chain of events results in a procoagulant and pro-inflammatory state typical of severe S. pyogenes infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/607215
- author
- Shannon, Oonagh LU ; Hertzén, Erika ; Norrby-Teglund, Anna ; Mörgelin, Matthias LU ; Sjöbring, Ulf LU and Björck, Lars LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Microbiology
- volume
- 65
- issue
- 5
- pages
- 1147 - 1157
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000249242300001
- scopus:34547909609
- ISSN
- 1365-2958
- DOI
- 10.1111/j.1365-2958.2007.05841.x
- language
- English
- LU publication?
- yes
- id
- 164d77fc-d953-41e6-be96-5bee728ee62f (old id 607215)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17662041&dopt=Abstract
- date added to LUP
- 2016-04-01 12:18:19
- date last changed
- 2022-03-13 08:06:55
@article{164d77fc-d953-41e6-be96-5bee728ee62f,
abstract = {{Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet aggregation and the generation of platelet-rich thrombi. Neutrophils and monocytes are in turn activated by the platelets. Platelet thrombi are deposited in the microvasculature, and aggregated platelets, IgG and M1 protein colocalize in biopsies from patients diagnosed with S. pyogenes toxic shock syndrome. This chain of events results in a procoagulant and pro-inflammatory state typical of severe S. pyogenes infection.}},
author = {{Shannon, Oonagh and Hertzén, Erika and Norrby-Teglund, Anna and Mörgelin, Matthias and Sjöbring, Ulf and Björck, Lars}},
issn = {{1365-2958}},
language = {{eng}},
number = {{5}},
pages = {{1147--1157}},
publisher = {{Wiley-Blackwell}},
series = {{Molecular Microbiology}},
title = {{Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.}},
url = {{https://lup.lub.lu.se/search/files/2868418/626114.pdf}},
doi = {{10.1111/j.1365-2958.2007.05841.x}},
volume = {{65}},
year = {{2007}},
}