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Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.

Shannon, Oonagh LU ; Hertzén, Erika; Norrby-Teglund, Anna; Mörgelin, Matthias LU ; Sjöbring, Ulf LU and Björck, Lars LU (2007) In Molecular Microbiology 65(5). p.1147-1157
Abstract
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet... (More)
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet aggregation and the generation of platelet-rich thrombi. Neutrophils and monocytes are in turn activated by the platelets. Platelet thrombi are deposited in the microvasculature, and aggregated platelets, IgG and M1 protein colocalize in biopsies from patients diagnosed with S. pyogenes toxic shock syndrome. This chain of events results in a procoagulant and pro-inflammatory state typical of severe S. pyogenes infection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Microbiology
volume
65
issue
5
pages
1147 - 1157
publisher
Wiley-Blackwell
external identifiers
  • wos:000249242300001
  • scopus:34547909609
ISSN
1365-2958
DOI
10.1111/j.1365-2958.2007.05841.x
language
English
LU publication?
yes
id
164d77fc-d953-41e6-be96-5bee728ee62f (old id 607215)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17662041&dopt=Abstract
date added to LUP
2008-01-02 15:24:44
date last changed
2017-05-02 11:36:44
@article{164d77fc-d953-41e6-be96-5bee728ee62f,
  abstract     = {Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released from the bacterial surface and forms complexes with plasma fibrinogen. These complexes bind to the fibrinogen receptor on resting platelets. When these complexes also contain immunoglobulin G (IgG) against M1 protein, this will engage the Fc receptor on the platelets and activation will occur. Activation of the platelets leads to platelet aggregation and the generation of platelet-rich thrombi. Neutrophils and monocytes are in turn activated by the platelets. Platelet thrombi are deposited in the microvasculature, and aggregated platelets, IgG and M1 protein colocalize in biopsies from patients diagnosed with S. pyogenes toxic shock syndrome. This chain of events results in a procoagulant and pro-inflammatory state typical of severe S. pyogenes infection.},
  author       = {Shannon, Oonagh and Hertzén, Erika and Norrby-Teglund, Anna and Mörgelin, Matthias and Sjöbring, Ulf and Björck, Lars},
  issn         = {1365-2958},
  language     = {eng},
  number       = {5},
  pages        = {1147--1157},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Microbiology},
  title        = {Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.},
  url          = {http://dx.doi.org/10.1111/j.1365-2958.2007.05841.x},
  volume       = {65},
  year         = {2007},
}