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Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes.

Nilsson, Bengt-Olof LU (2007) In Inflammation Research 56(7). p.269-273
Abstract
Gender differences and variations in inflammatory disease (e. g. atherosclerosis, neurological disorders, periodontitis and rheumatoid arthritis) severity with female sex hormone level have been reported, suggesting that female sex hormones modulate the inflammatory response. Estrogens act on gene transcription via estrogen receptors alpha and beta. Identification of estrogen-regulated genes is a matter of great interest since it will contribute significantly to the understanding of the physiological importance of estrogens. Anti-inflammatory as well as pro-inflammatory responses to estrogens have been reported. Data have been presented showing that estrogens down-regulate the expression of adhesion and chemokine molecules in response to... (More)
Gender differences and variations in inflammatory disease (e. g. atherosclerosis, neurological disorders, periodontitis and rheumatoid arthritis) severity with female sex hormone level have been reported, suggesting that female sex hormones modulate the inflammatory response. Estrogens act on gene transcription via estrogen receptors alpha and beta. Identification of estrogen-regulated genes is a matter of great interest since it will contribute significantly to the understanding of the physiological importance of estrogens. Anti-inflammatory as well as pro-inflammatory responses to estrogens have been reported. Data have been presented showing that estrogens down-regulate the expression of adhesion and chemokine molecules in response to inflammation promoters in various experimental systems. Functional data show that estrogen treatment attenuates recruitment and adhesion of leukocytes to the endothelium induced by inflammation promoters offering a possible mechanism by which estrogens exert an anti-inflammatory effect. These effects of estrogens, with focus on the interactions of monocytes with the vascular endothelium, are highlighted in this review. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endothelium, nitric oxide synthase, cytokines, estrogen, chemokines
in
Inflammation Research
volume
56
issue
7
pages
269 - 273
publisher
Birkhaüser
external identifiers
  • wos:000248228400001
  • scopus:34547107626
ISSN
1420-908X
DOI
10.1007/s00011-007-6198-z
language
English
LU publication?
yes
id
22cf174b-5052-4907-944b-5ae82698acf4 (old id 607252)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17659431&dopt=Abstract
date added to LUP
2007-12-18 17:00:52
date last changed
2017-09-10 03:49:16
@article{22cf174b-5052-4907-944b-5ae82698acf4,
  abstract     = {Gender differences and variations in inflammatory disease (e. g. atherosclerosis, neurological disorders, periodontitis and rheumatoid arthritis) severity with female sex hormone level have been reported, suggesting that female sex hormones modulate the inflammatory response. Estrogens act on gene transcription via estrogen receptors alpha and beta. Identification of estrogen-regulated genes is a matter of great interest since it will contribute significantly to the understanding of the physiological importance of estrogens. Anti-inflammatory as well as pro-inflammatory responses to estrogens have been reported. Data have been presented showing that estrogens down-regulate the expression of adhesion and chemokine molecules in response to inflammation promoters in various experimental systems. Functional data show that estrogen treatment attenuates recruitment and adhesion of leukocytes to the endothelium induced by inflammation promoters offering a possible mechanism by which estrogens exert an anti-inflammatory effect. These effects of estrogens, with focus on the interactions of monocytes with the vascular endothelium, are highlighted in this review.},
  author       = {Nilsson, Bengt-Olof},
  issn         = {1420-908X},
  keyword      = {endothelium,nitric oxide synthase,cytokines,estrogen,chemokines},
  language     = {eng},
  number       = {7},
  pages        = {269--273},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research},
  title        = {Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes.},
  url          = {http://dx.doi.org/10.1007/s00011-007-6198-z},
  volume       = {56},
  year         = {2007},
}