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Cutaneous human papillomavirus 88: Remarkable differences in viral load.

Ekström, Johanna LU ; Handisurya, Alessandra; Forslund, Ola LU ; Geusau, Alexandra; Kirnbauer, Reinhard and Dillner, Joakim LU (2008) In International Journal of Cancer 122(2). p.477-480
Abstract
A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79 actinic keratoses, 73 seborrhoeic keratoses, 169 basal cell carcinomas and 126 SCCs) and 362 healthy skin biopsies found detectable HPV88 DNA in only 7 specimens. All these had very low viral loads (<1 copy/10(3) cells) implying extreme biological variability in viral load.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
122
issue
2
pages
477 - 480
publisher
John Wiley & Sons
external identifiers
  • wos:000251704400031
  • scopus:36849054070
ISSN
0020-7136
DOI
10.1002/ijc.23115
language
English
LU publication?
yes
id
1ac0623c-7ca9-40e3-b4bf-0852c092dad0 (old id 608603)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17935140&dopt=Abstract
date added to LUP
2008-08-04 15:41:19
date last changed
2017-01-01 04:45:08
@article{1ac0623c-7ca9-40e3-b4bf-0852c092dad0,
  abstract     = {A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79 actinic keratoses, 73 seborrhoeic keratoses, 169 basal cell carcinomas and 126 SCCs) and 362 healthy skin biopsies found detectable HPV88 DNA in only 7 specimens. All these had very low viral loads (&lt;1 copy/10(3) cells) implying extreme biological variability in viral load.},
  author       = {Ekström, Johanna and Handisurya, Alessandra and Forslund, Ola and Geusau, Alexandra and Kirnbauer, Reinhard and Dillner, Joakim},
  issn         = {0020-7136},
  language     = {eng},
  number       = {2},
  pages        = {477--480},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Cutaneous human papillomavirus 88: Remarkable differences in viral load.},
  url          = {http://dx.doi.org/10.1002/ijc.23115},
  volume       = {122},
  year         = {2008},
}