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Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients

Wang, Xiao LU ; Sundquist, Kristina LU ; Rastkhani, Hamideh LU ; Palmér, Karolina LU ; Memon, Ashfaque A. LU orcid and Sundquist, Jan LU (2017) In European Neuropsychopharmacology 27(8). p.751-758
Abstract

Mitochondrial dysfunction may result in a variety of diseases. The objectives here were to examine possible differences in mtDNA copy number between healthy controls and patients with depression, anxiety or stress- and adjustment disorders; the association between mtDNA copy number and disease severity at baseline; and the association between mtDNA copy number and response after an 8-week treatment (mindfulness, cognitive based therapy). A total of 179 patients in primary health care (age 20-64 years) with depression, anxiety and stress- and adjustment disorders, and 320 healthy controls (aged 19-70 years) were included in the study. Relative mtDNA copy number was measured using quantitative real-time PCR on peripheral blood samples. We... (More)

Mitochondrial dysfunction may result in a variety of diseases. The objectives here were to examine possible differences in mtDNA copy number between healthy controls and patients with depression, anxiety or stress- and adjustment disorders; the association between mtDNA copy number and disease severity at baseline; and the association between mtDNA copy number and response after an 8-week treatment (mindfulness, cognitive based therapy). A total of 179 patients in primary health care (age 20-64 years) with depression, anxiety and stress- and adjustment disorders, and 320 healthy controls (aged 19-70 years) were included in the study. Relative mtDNA copy number was measured using quantitative real-time PCR on peripheral blood samples. We found that the mean mtDNA copy number was significantly higher in patients compared to controls (84.9 vs 75.9, p<0.0001) at baseline. The difference in mtDNA copy number between patients and controls remained significant after controlling for age and sex (ß=8.13, p<0.0001; linear regression analysis). The mtDNA copy number was significantly associated with Patient Health Questionnaire (PHQ-9) scores (β=0.57, p=0.02) at baseline. After treatment, the change in mtDNA copy number was significantly associated with the treatment response, i.e., change in Hospital Anxiety and Depression Scale (HADS-D) and PHQ-9 scores (ß=1.00, p=0.03 and ß=0.65, p=0.04, respectively), after controlling for baseline scores, age, sex, BMI, smoking status, alcohol drinking and medication. Our findings show that mtDNA copy number is associated with symptoms of depression, anxiety and stress- and adjustment disorders and treatment response in these disorders.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anxiety, Depression, MtDNA, Stress- and adjustment disorders
in
European Neuropsychopharmacology
volume
27
issue
8
pages
751 - 758
publisher
Elsevier
external identifiers
  • pmid:28647451
  • wos:000407055700005
  • scopus:85021113541
ISSN
0924-977X
DOI
10.1016/j.euroneuro.2017.06.001
language
English
LU publication?
yes
id
60d3d42e-6f5f-42ad-96bc-a34737af3b38
date added to LUP
2017-08-18 08:50:41
date last changed
2025-01-07 18:51:00
@article{60d3d42e-6f5f-42ad-96bc-a34737af3b38,
  abstract     = {{<p>Mitochondrial dysfunction may result in a variety of diseases. The objectives here were to examine possible differences in mtDNA copy number between healthy controls and patients with depression, anxiety or stress- and adjustment disorders; the association between mtDNA copy number and disease severity at baseline; and the association between mtDNA copy number and response after an 8-week treatment (mindfulness, cognitive based therapy). A total of 179 patients in primary health care (age 20-64 years) with depression, anxiety and stress- and adjustment disorders, and 320 healthy controls (aged 19-70 years) were included in the study. Relative mtDNA copy number was measured using quantitative real-time PCR on peripheral blood samples. We found that the mean mtDNA copy number was significantly higher in patients compared to controls (84.9 vs 75.9, p&lt;0.0001) at baseline. The difference in mtDNA copy number between patients and controls remained significant after controlling for age and sex (ß=8.13, p&lt;0.0001; linear regression analysis). The mtDNA copy number was significantly associated with Patient Health Questionnaire (PHQ-9) scores (β=0.57, p=0.02) at baseline. After treatment, the change in mtDNA copy number was significantly associated with the treatment response, i.e., change in Hospital Anxiety and Depression Scale (HADS-D) and PHQ-9 scores (ß=1.00, p=0.03 and ß=0.65, p=0.04, respectively), after controlling for baseline scores, age, sex, BMI, smoking status, alcohol drinking and medication. Our findings show that mtDNA copy number is associated with symptoms of depression, anxiety and stress- and adjustment disorders and treatment response in these disorders.</p>}},
  author       = {{Wang, Xiao and Sundquist, Kristina and Rastkhani, Hamideh and Palmér, Karolina and Memon, Ashfaque A. and Sundquist, Jan}},
  issn         = {{0924-977X}},
  keywords     = {{Anxiety; Depression; MtDNA; Stress- and adjustment disorders}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{751--758}},
  publisher    = {{Elsevier}},
  series       = {{European Neuropsychopharmacology}},
  title        = {{Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients}},
  url          = {{http://dx.doi.org/10.1016/j.euroneuro.2017.06.001}},
  doi          = {{10.1016/j.euroneuro.2017.06.001}},
  volume       = {{27}},
  year         = {{2017}},
}