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Five year risk assessment and treatment patterns in patients with chronic thromboembolic pulmonary hypertension

Kjellström, Barbro LU ; Bouzina, Habib LU ; Björklund, Erik ; Beaudet, Amélie ; Edwards, Susan C. ; Hesselstrand, Roger LU ; Jansson, Kjell ; Nisell, Magnus ; Rådegran, Göran LU and Sandqvist, Anna , et al. (2022) In ESC Heart Failure 9(5). p.3264-3274
Abstract

Aims: Repeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period. Methods and results: Descriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swedish pulmonary hypertension registry, stratified by pulmonary endarterectomy surgery (PEA). Risk and PH-specific treatment were assessed in surgically treated (PEA) and medically treated (non-PEA) patients at diagnosis and up to 5 years follow-up. Data are presented as median (Q1–Q3), count or per cent. Prior to surgery, 63% in the PEA-group [n... (More)

Aims: Repeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period. Methods and results: Descriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swedish pulmonary hypertension registry, stratified by pulmonary endarterectomy surgery (PEA). Risk and PH-specific treatment were assessed in surgically treated (PEA) and medically treated (non-PEA) patients at diagnosis and up to 5 years follow-up. Data are presented as median (Q1–Q3), count or per cent. Prior to surgery, 63% in the PEA-group [n = 98, age 64 (51–71) years, 37% female] used PH-specific treatment and 20, 69, and 10% were assessed as low, intermediate or high risk, respectively. After 1 year post-surgery, 34% had no PH-specific treatment or follow-up visit registered despite being alive at 5 years. Of patients with a 5 year visit (n = 23), 46% were at low and 54% at intermediate risk, while 91% used PH-specific treatment. In the non-PEA group [n = 213, age 72 (65–77) years, 56% female], 28% were assessed as low, 61% as intermediate and 11% as high risk. All patients at high risk versus 50% at low risk used PH-specific treatment. The 1 year mortality was 6%, while the risk was unchanged in 57% of the patients; 14% improved from intermediate to low risk, and 1% from high to low risk. At 5 years, 27% had a registered visit and 28% had died. Of patients with a 5 year visit (n = 58), 38% were at low, 59% at intermediate and 1% at high risk, and 86% used PH-specific treatment. Conclusions: Risk status assessed pre-surgery did not foresee long-term post-PEA risk and pre-surgery PH-specific treatment did not foresee long-term post-PEA treatment. Medically treated CTEPH patients tend to remain at the same risk over time, suggesting a need for improved treatment strategies in this group.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pulmonary endarterectomy, Pulmonary hypertension, Risk assessment
in
ESC Heart Failure
volume
9
issue
5
pages
3264 - 3274
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:35789127
  • scopus:85133366635
ISSN
2055-5822
DOI
10.1002/ehf2.14033
language
English
LU publication?
yes
id
60e6f11e-0ffa-454b-8821-52a7c9751418
date added to LUP
2022-10-07 11:10:04
date last changed
2024-05-30 20:40:39
@article{60e6f11e-0ffa-454b-8821-52a7c9751418,
  abstract     = {{<p>Aims: Repeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period. Methods and results: Descriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swedish pulmonary hypertension registry, stratified by pulmonary endarterectomy surgery (PEA). Risk and PH-specific treatment were assessed in surgically treated (PEA) and medically treated (non-PEA) patients at diagnosis and up to 5 years follow-up. Data are presented as median (Q1–Q3), count or per cent. Prior to surgery, 63% in the PEA-group [n = 98, age 64 (51–71) years, 37% female] used PH-specific treatment and 20, 69, and 10% were assessed as low, intermediate or high risk, respectively. After 1 year post-surgery, 34% had no PH-specific treatment or follow-up visit registered despite being alive at 5 years. Of patients with a 5 year visit (n = 23), 46% were at low and 54% at intermediate risk, while 91% used PH-specific treatment. In the non-PEA group [n = 213, age 72 (65–77) years, 56% female], 28% were assessed as low, 61% as intermediate and 11% as high risk. All patients at high risk versus 50% at low risk used PH-specific treatment. The 1 year mortality was 6%, while the risk was unchanged in 57% of the patients; 14% improved from intermediate to low risk, and 1% from high to low risk. At 5 years, 27% had a registered visit and 28% had died. Of patients with a 5 year visit (n = 58), 38% were at low, 59% at intermediate and 1% at high risk, and 86% used PH-specific treatment. Conclusions: Risk status assessed pre-surgery did not foresee long-term post-PEA risk and pre-surgery PH-specific treatment did not foresee long-term post-PEA treatment. Medically treated CTEPH patients tend to remain at the same risk over time, suggesting a need for improved treatment strategies in this group.</p>}},
  author       = {{Kjellström, Barbro and Bouzina, Habib and Björklund, Erik and Beaudet, Amélie and Edwards, Susan C. and Hesselstrand, Roger and Jansson, Kjell and Nisell, Magnus and Rådegran, Göran and Sandqvist, Anna and Wåhlander, Håkan and Hjalmarsson, Clara and Söderberg, Stefan}},
  issn         = {{2055-5822}},
  keywords     = {{Pulmonary endarterectomy; Pulmonary hypertension; Risk assessment}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{3264--3274}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ESC Heart Failure}},
  title        = {{Five year risk assessment and treatment patterns in patients with chronic thromboembolic pulmonary hypertension}},
  url          = {{http://dx.doi.org/10.1002/ehf2.14033}},
  doi          = {{10.1002/ehf2.14033}},
  volume       = {{9}},
  year         = {{2022}},
}