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Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP) : mechanisms of action

Lazarus, A H ; Freedman, J and Semple, J W LU (1998) In Transfusion Science 19(3). p.94-289
Abstract

Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibodies, Anti-Idiotypic/immunology, Autoantibodies/immunology, Autoimmune Diseases/immunology, Blood Platelets/immunology, Clinical Trials as Topic, Half-Life, Humans, Immunoglobulin G/immunology, Immunoglobulin M/immunology, Immunoglobulins, Intravenous/therapeutic use, Isoantibodies/therapeutic use, Macrophage Activation, Mononuclear Phagocyte System/physiopathology, Purpura, Thrombocytopenic, Idiopathic/immunology, Rho(D) Immune Globulin
in
Transfusion Science
volume
19
issue
3
pages
94 - 289
publisher
Pergamon Press Ltd.
external identifiers
  • pmid:10351141
  • scopus:0346390594
ISSN
0955-3886
DOI
10.1016/s0955-3886(98)00043-5
language
English
LU publication?
no
id
61054f2b-197b-49c5-b9d9-0a786283d51b
date added to LUP
2022-11-09 15:27:42
date last changed
2024-05-31 22:39:42
@article{61054f2b-197b-49c5-b9d9-0a786283d51b,
  abstract     = {{<p>Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.</p>}},
  author       = {{Lazarus, A H and Freedman, J and Semple, J W}},
  issn         = {{0955-3886}},
  keywords     = {{Antibodies, Anti-Idiotypic/immunology; Autoantibodies/immunology; Autoimmune Diseases/immunology; Blood Platelets/immunology; Clinical Trials as Topic; Half-Life; Humans; Immunoglobulin G/immunology; Immunoglobulin M/immunology; Immunoglobulins, Intravenous/therapeutic use; Isoantibodies/therapeutic use; Macrophage Activation; Mononuclear Phagocyte System/physiopathology; Purpura, Thrombocytopenic, Idiopathic/immunology; Rho(D) Immune Globulin}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{94--289}},
  publisher    = {{Pergamon Press Ltd.}},
  series       = {{Transfusion Science}},
  title        = {{Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP) : mechanisms of action}},
  url          = {{http://dx.doi.org/10.1016/s0955-3886(98)00043-5}},
  doi          = {{10.1016/s0955-3886(98)00043-5}},
  volume       = {{19}},
  year         = {{1998}},
}