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Compact fiber-optic fluorosensor using high-power continuous-wave violet diode laser

Johansson, Ann LU ; Gustafsson, Ulf; Pålsson, Sara LU and Svanberg, Sune LU (2003) Diagnostic Optical Spectroscopy in Biomedicine II In Proceedings of SPIE - The International Society for Optical Engineering 5141. p.47-57
Abstract
In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compact. The high laser output power allows for coupling of the laser light into a hyperspectral diagnostic imaging instrument, developed and built by Science and Technology International. In point-monitoring mode, the instrument has been tested on superficial skin tumors and when using δ-aminolevulinic acid induced protoporphyrin IX as a tumor... (More)
In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compact. The high laser output power allows for coupling of the laser light into a hyperspectral diagnostic imaging instrument, developed and built by Science and Technology International. In point-monitoring mode, the instrument has been tested on superficial skin tumors and when using δ-aminolevulinic acid induced protoporphyrin IX as a tumor sensitizer, good contrast between normal and malignant tissue was achieved, clearly demonstrating its feasibility in cancer diagnostics. In imaging mode, the instrument functioned solely as a light source, coupling the excitation light into the hyperspectral imaging instrument. The set-up was tested by studying chlorophyll fluorescence from vegetation. The fluorescence signal showed a low signal-to-noise ratio mainly because of inefficient light coupling into the imaging instrument. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Compact fiber optic fluorosensor, Malignant tissue, Vegetation imaging, Cancer diagnostic, Protoporphyrin, Aminolevulinic acid, Laser induced fluorescence, High power continuous wave violet diode laser
in
Proceedings of SPIE - The International Society for Optical Engineering
volume
5141
pages
47 - 57
publisher
The International Society for Optical Engineering
conference name
Diagnostic Optical Spectroscopy in Biomedicine II
external identifiers
  • wos:000186471600007
  • other:CODEN: PSISDG
  • scopus:1342283948
ISSN
1996-756X
0277-786X
DOI
language
English
LU publication?
yes
id
3f3a8b20-2636-4556-99dd-077f8dc490ee (old id 613060)
date added to LUP
2007-11-30 10:41:29
date last changed
2018-05-29 09:35:01
@inproceedings{3f3a8b20-2636-4556-99dd-077f8dc490ee,
  abstract     = {In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compact. The high laser output power allows for coupling of the laser light into a hyperspectral diagnostic imaging instrument, developed and built by Science and Technology International. In point-monitoring mode, the instrument has been tested on superficial skin tumors and when using δ-aminolevulinic acid induced protoporphyrin IX as a tumor sensitizer, good contrast between normal and malignant tissue was achieved, clearly demonstrating its feasibility in cancer diagnostics. In imaging mode, the instrument functioned solely as a light source, coupling the excitation light into the hyperspectral imaging instrument. The set-up was tested by studying chlorophyll fluorescence from vegetation. The fluorescence signal showed a low signal-to-noise ratio mainly because of inefficient light coupling into the imaging instrument.},
  author       = {Johansson, Ann and Gustafsson, Ulf and Pålsson, Sara and Svanberg, Sune},
  booktitle    = {Proceedings of SPIE - The International Society for Optical Engineering},
  issn         = {1996-756X},
  keyword      = {Compact fiber optic fluorosensor,Malignant tissue,Vegetation imaging,Cancer diagnostic,Protoporphyrin,Aminolevulinic acid,Laser induced fluorescence,High power continuous wave violet diode laser},
  language     = {eng},
  pages        = {47--57},
  publisher    = {The International Society for Optical Engineering},
  title        = {Compact fiber-optic fluorosensor using high-power continuous-wave violet diode laser},
  url          = {http://dx.doi.org/},
  volume       = {5141},
  year         = {2003},
}