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Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Xie, Maomao ; Gao, Meng ; Yun, Yang ; Malmsten, Martin LU ; Rotello, Vincent M. ; Zboril, Radek ; Akhavan, Omid ; Kraskouski, Aliaksandr ; Amalraj, John and Cai, Xiaoming , et al. (2023) In Angewandte Chemie - International Edition 62(17).
Abstract

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial... (More)

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibacterial Nanomaterials, Antimicrobial Resistance, Killing Mechanism, Nano-Bio Interaction, Structure-Activity Relationship
in
Angewandte Chemie - International Edition
volume
62
issue
17
article number
e202217345
pages
25 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85147919108
  • pmid:36718001
ISSN
1433-7851
DOI
10.1002/anie.202217345
language
English
LU publication?
yes
id
61996a5d-1f41-4898-b493-7973d8ee6b46
date added to LUP
2023-03-08 11:30:33
date last changed
2024-06-14 16:06:44
@article{61996a5d-1f41-4898-b493-7973d8ee6b46,
  abstract     = {{<p>Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.</p>}},
  author       = {{Xie, Maomao and Gao, Meng and Yun, Yang and Malmsten, Martin and Rotello, Vincent M. and Zboril, Radek and Akhavan, Omid and Kraskouski, Aliaksandr and Amalraj, John and Cai, Xiaoming and Lu, Jianmei and Zheng, Huizhen and Li, Ruibin}},
  issn         = {{1433-7851}},
  keywords     = {{Antibacterial Nanomaterials; Antimicrobial Resistance; Killing Mechanism; Nano-Bio Interaction; Structure-Activity Relationship}},
  language     = {{eng}},
  number       = {{17}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Angewandte Chemie - International Edition}},
  title        = {{Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles}},
  url          = {{http://dx.doi.org/10.1002/anie.202217345}},
  doi          = {{10.1002/anie.202217345}},
  volume       = {{62}},
  year         = {{2023}},
}