Challenges and considerations in diagnosing the kidney disease in deteriorating graft function.
(2012) In Transplant international : official journal of the European Society for Organ Transplantation 25(11). p.1119-1128- Abstract
- Despite significant reductions in acute-rejection rates with the introduction of calcineurin inhibitor (CNI)-based immunosuppressive therapy, improvements in long-term graft survival in renal transplantation have been mixed. Improving long-term graft survival continues to present a major challenge in the management of kidney-transplant patients. CNIs are a key component of immunosuppressive therapy, and chronic CNI toxicity has been widely thought to be a major factor in late graft failure. However, recent studies examining the causes of late graft failure in detail have challenged this view, highlighting the importance of antibody-mediated rejection and other factors. In addition, the diagnosis of CNI nephrotoxicity represents a challenge... (More)
- Despite significant reductions in acute-rejection rates with the introduction of calcineurin inhibitor (CNI)-based immunosuppressive therapy, improvements in long-term graft survival in renal transplantation have been mixed. Improving long-term graft survival continues to present a major challenge in the management of kidney-transplant patients. CNIs are a key component of immunosuppressive therapy, and chronic CNI toxicity has been widely thought to be a major factor in late graft failure. However, recent studies examining the causes of late graft failure in detail have challenged this view, highlighting the importance of antibody-mediated rejection and other factors. In addition, the diagnosis of CNI nephrotoxicity represents a challenge to clinicians, with the potential for over-diagnosis and an inappropriate reduction in immunosuppressive therapy. When graft function is deteriorating, accurately determining the cause of the kidney disease is essential for effective long-term management of the patient. Diagnosis requires a thorough clinical investigation, and in the majority of cases a specific cause can be identified. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2858916
- author
- Ekberg, Henrik LU and Johansson, Martin E
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transplant international : official journal of the European Society for Organ Transplantation
- volume
- 25
- issue
- 11
- pages
- 1119 - 1128
- publisher
- Springer
- external identifiers
-
- wos:000309748700004
- pmid:22738034
- scopus:84867529594
- pmid:22738034
- ISSN
- 1432-2277
- DOI
- 10.1111/j.1432-2277.2012.01516.x
- language
- English
- LU publication?
- yes
- id
- 61aa7439-8dc3-4e4e-b10f-764116a7aa1e (old id 2858916)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22738034?dopt=Abstract
- date added to LUP
- 2016-04-04 09:33:51
- date last changed
- 2022-04-23 21:12:05
@article{61aa7439-8dc3-4e4e-b10f-764116a7aa1e,
abstract = {{Despite significant reductions in acute-rejection rates with the introduction of calcineurin inhibitor (CNI)-based immunosuppressive therapy, improvements in long-term graft survival in renal transplantation have been mixed. Improving long-term graft survival continues to present a major challenge in the management of kidney-transplant patients. CNIs are a key component of immunosuppressive therapy, and chronic CNI toxicity has been widely thought to be a major factor in late graft failure. However, recent studies examining the causes of late graft failure in detail have challenged this view, highlighting the importance of antibody-mediated rejection and other factors. In addition, the diagnosis of CNI nephrotoxicity represents a challenge to clinicians, with the potential for over-diagnosis and an inappropriate reduction in immunosuppressive therapy. When graft function is deteriorating, accurately determining the cause of the kidney disease is essential for effective long-term management of the patient. Diagnosis requires a thorough clinical investigation, and in the majority of cases a specific cause can be identified.}},
author = {{Ekberg, Henrik and Johansson, Martin E}},
issn = {{1432-2277}},
language = {{eng}},
number = {{11}},
pages = {{1119--1128}},
publisher = {{Springer}},
series = {{Transplant international : official journal of the European Society for Organ Transplantation}},
title = {{Challenges and considerations in diagnosing the kidney disease in deteriorating graft function.}},
url = {{http://dx.doi.org/10.1111/j.1432-2277.2012.01516.x}},
doi = {{10.1111/j.1432-2277.2012.01516.x}},
volume = {{25}},
year = {{2012}},
}