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The association of mitochondrial DNA copy number with incident mental disorders in women : A population-based follow-up study

Wang, Xiao LU ; Memon, Ashfaque A LU orcid ; Palmér, Karolina LU ; Hedelius, Anna LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2022) In Journal of Affective Disorders 308. p.111-115
Abstract

BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.

MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.

RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN < 117) was... (More)

BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.

MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.

RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN < 117) was associated with a higher risk of mental disorders (HR = 1.16, p = 0.047). In addition, smoking, marital status and sleeping quality were associated with both mtDNA-CN and mental disorders. After adjusting for these variables, the association between mtDNA-CN and mental disorders decreased and became non-significant (HR = 1.07, p = 0.36). Stratification of data according to the subtype of mental disorders, showed that low mtDNA-CN was associated with a higher risk of alcohol or drug use disorders (HR = 1.82, p = 0.045 after adjusting).

CONCLUSION: In the present study, we could not find any independent association between mtDNA-CN blood and the most common mental disorders in a population-based follow-up study of Swedish women, except for alcohol and drug use disorders. The use of blood mtDNA-CN as a biomarker of mental disorders, in addition to other risk factors, needs to be further examined in future studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
308
pages
111 - 115
publisher
Elsevier
external identifiers
  • pmid:35427715
  • scopus:85128310956
ISSN
0165-0327
DOI
10.1016/j.jad.2022.04.064
language
English
LU publication?
yes
id
61b6d294-1eeb-4c38-8dd8-633431eacdac
date added to LUP
2022-04-25 15:10:51
date last changed
2024-08-08 17:00:33
@article{61b6d294-1eeb-4c38-8dd8-633431eacdac,
  abstract     = {{<p>BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.</p><p>MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.</p><p>RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN &lt; 117) was associated with a higher risk of mental disorders (HR = 1.16, p = 0.047). In addition, smoking, marital status and sleeping quality were associated with both mtDNA-CN and mental disorders. After adjusting for these variables, the association between mtDNA-CN and mental disorders decreased and became non-significant (HR = 1.07, p = 0.36). Stratification of data according to the subtype of mental disorders, showed that low mtDNA-CN was associated with a higher risk of alcohol or drug use disorders (HR = 1.82, p = 0.045 after adjusting).</p><p>CONCLUSION: In the present study, we could not find any independent association between mtDNA-CN blood and the most common mental disorders in a population-based follow-up study of Swedish women, except for alcohol and drug use disorders. The use of blood mtDNA-CN as a biomarker of mental disorders, in addition to other risk factors, needs to be further examined in future studies.</p>}},
  author       = {{Wang, Xiao and Memon, Ashfaque A and Palmér, Karolina and Hedelius, Anna and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{0165-0327}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{111--115}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders}},
  title        = {{The association of mitochondrial DNA copy number with incident mental disorders in women : A population-based follow-up study}},
  url          = {{http://dx.doi.org/10.1016/j.jad.2022.04.064}},
  doi          = {{10.1016/j.jad.2022.04.064}},
  volume       = {{308}},
  year         = {{2022}},
}