The association of mitochondrial DNA copy number with incident mental disorders in women : A population-based follow-up study
(2022) In Journal of Affective Disorders 308. p.111-115- Abstract
BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.
MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.
RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN < 117) was... (More)
BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.
MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.
RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN < 117) was associated with a higher risk of mental disorders (HR = 1.16, p = 0.047). In addition, smoking, marital status and sleeping quality were associated with both mtDNA-CN and mental disorders. After adjusting for these variables, the association between mtDNA-CN and mental disorders decreased and became non-significant (HR = 1.07, p = 0.36). Stratification of data according to the subtype of mental disorders, showed that low mtDNA-CN was associated with a higher risk of alcohol or drug use disorders (HR = 1.82, p = 0.045 after adjusting).
CONCLUSION: In the present study, we could not find any independent association between mtDNA-CN blood and the most common mental disorders in a population-based follow-up study of Swedish women, except for alcohol and drug use disorders. The use of blood mtDNA-CN as a biomarker of mental disorders, in addition to other risk factors, needs to be further examined in future studies.
(Less)
- author
- Wang, Xiao
LU
; Memon, Ashfaque A
LU
; Palmér, Karolina LU ; Hedelius, Anna LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2022-04-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Affective Disorders
- volume
- 308
- pages
- 111 - 115
- publisher
- Elsevier
- external identifiers
-
- pmid:35427715
- scopus:85128310956
- ISSN
- 0165-0327
- DOI
- 10.1016/j.jad.2022.04.064
- language
- English
- LU publication?
- yes
- id
- 61b6d294-1eeb-4c38-8dd8-633431eacdac
- date added to LUP
- 2022-04-25 15:10:51
- date last changed
- 2024-08-08 17:00:33
@article{61b6d294-1eeb-4c38-8dd8-633431eacdac, abstract = {{<p>BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.</p><p>MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained from a population-based follow-up study, which included a total of 2354 middle-aged women (52-63 years) who were free of mental disorders at baseline. After 17 years (median) of follow-up, 727 participants were diagnosed with mental disorders.</p><p>RESULTS: In the univariate Cox regression, lower baseline mtDNA-CN (mtDNA-CN < 117) was associated with a higher risk of mental disorders (HR = 1.16, p = 0.047). In addition, smoking, marital status and sleeping quality were associated with both mtDNA-CN and mental disorders. After adjusting for these variables, the association between mtDNA-CN and mental disorders decreased and became non-significant (HR = 1.07, p = 0.36). Stratification of data according to the subtype of mental disorders, showed that low mtDNA-CN was associated with a higher risk of alcohol or drug use disorders (HR = 1.82, p = 0.045 after adjusting).</p><p>CONCLUSION: In the present study, we could not find any independent association between mtDNA-CN blood and the most common mental disorders in a population-based follow-up study of Swedish women, except for alcohol and drug use disorders. The use of blood mtDNA-CN as a biomarker of mental disorders, in addition to other risk factors, needs to be further examined in future studies.</p>}}, author = {{Wang, Xiao and Memon, Ashfaque A and Palmér, Karolina and Hedelius, Anna and Sundquist, Jan and Sundquist, Kristina}}, issn = {{0165-0327}}, language = {{eng}}, month = {{04}}, pages = {{111--115}}, publisher = {{Elsevier}}, series = {{Journal of Affective Disorders}}, title = {{The association of mitochondrial DNA copy number with incident mental disorders in women : A population-based follow-up study}}, url = {{http://dx.doi.org/10.1016/j.jad.2022.04.064}}, doi = {{10.1016/j.jad.2022.04.064}}, volume = {{308}}, year = {{2022}}, }