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Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin

Christensen, Gustav Boelsgaard LU ; Nagaoka, Takashi ; Kiyohara, Yoshio ; Johansson, Iva LU ; Ingvar, Christian LU ; Nakamura, Atsushi ; Sota, Takayuki and Nielsen, Kari LU orcid (2021) In Skin Research and Technology
Abstract

Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used... (More)

Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used to demonstrate the sensitivity (SE) and specificity (SP) in comparison with the re-evaluated histopathology diagnoses. Results: In 186 patients, 202 pigmented skin lesions were included. The sensitivity to detect cMM was 96.7% (87/90), and the specificity for benign lesions was 42.1% (45/107). The AUC was 0.800 (95% confidence interval (CI): 0.740-0.861). Conclusions: Our novel HSI device showed a high sensitivity in detecting malignant lesions in patients with Caucasian skin types. Compared with analogous technologies, as multispectral imaging or electrical impedance spectroscopy, our device showed similar or better accuracy in differentiating cMM from benign PSLs. Therefore, it might be a useful clinical tool in skin types I-IV and where further triage of pigmented skin lesions is important.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Caucasian skin type, hyperspectral imaging, melanoma, pigmented skin lesions
in
Skin Research and Technology
publisher
Wiley-Blackwell
external identifiers
  • scopus:85101874531
  • pmid:33651425
ISSN
0909-752X
DOI
10.1111/srt.13023
language
English
LU publication?
yes
additional info
© 2021 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.
id
61f588ff-6d06-405f-9871-30ea7a891f69
date added to LUP
2021-03-17 10:39:06
date last changed
2024-06-13 08:57:32
@article{61f588ff-6d06-405f-9871-30ea7a891f69,
  abstract     = {{<p>Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used to demonstrate the sensitivity (SE) and specificity (SP) in comparison with the re-evaluated histopathology diagnoses. Results: In 186 patients, 202 pigmented skin lesions were included. The sensitivity to detect cMM was 96.7% (87/90), and the specificity for benign lesions was 42.1% (45/107). The AUC was 0.800 (95% confidence interval (CI): 0.740-0.861). Conclusions: Our novel HSI device showed a high sensitivity in detecting malignant lesions in patients with Caucasian skin types. Compared with analogous technologies, as multispectral imaging or electrical impedance spectroscopy, our device showed similar or better accuracy in differentiating cMM from benign PSLs. Therefore, it might be a useful clinical tool in skin types I-IV and where further triage of pigmented skin lesions is important.</p>}},
  author       = {{Christensen, Gustav Boelsgaard and Nagaoka, Takashi and Kiyohara, Yoshio and Johansson, Iva and Ingvar, Christian and Nakamura, Atsushi and Sota, Takayuki and Nielsen, Kari}},
  issn         = {{0909-752X}},
  keywords     = {{Caucasian skin type; hyperspectral imaging; melanoma; pigmented skin lesions}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Skin Research and Technology}},
  title        = {{Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin}},
  url          = {{http://dx.doi.org/10.1111/srt.13023}},
  doi          = {{10.1111/srt.13023}},
  year         = {{2021}},
}