Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin
(2021) In Skin Research and Technology- Abstract
Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used... (More)
Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used to demonstrate the sensitivity (SE) and specificity (SP) in comparison with the re-evaluated histopathology diagnoses. Results: In 186 patients, 202 pigmented skin lesions were included. The sensitivity to detect cMM was 96.7% (87/90), and the specificity for benign lesions was 42.1% (45/107). The AUC was 0.800 (95% confidence interval (CI): 0.740-0.861). Conclusions: Our novel HSI device showed a high sensitivity in detecting malignant lesions in patients with Caucasian skin types. Compared with analogous technologies, as multispectral imaging or electrical impedance spectroscopy, our device showed similar or better accuracy in differentiating cMM from benign PSLs. Therefore, it might be a useful clinical tool in skin types I-IV and where further triage of pigmented skin lesions is important.
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- author
- Christensen, Gustav Boelsgaard LU ; Nagaoka, Takashi ; Kiyohara, Yoshio ; Johansson, Iva LU ; Ingvar, Christian LU ; Nakamura, Atsushi ; Sota, Takayuki and Nielsen, Kari LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Caucasian skin type, hyperspectral imaging, melanoma, pigmented skin lesions
- in
- Skin Research and Technology
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33651425
- scopus:85101874531
- ISSN
- 0909-752X
- DOI
- 10.1111/srt.13023
- language
- English
- LU publication?
- yes
- additional info
- © 2021 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.
- id
- 61f588ff-6d06-405f-9871-30ea7a891f69
- date added to LUP
- 2021-03-17 10:39:06
- date last changed
- 2024-09-19 18:14:16
@article{61f588ff-6d06-405f-9871-30ea7a891f69, abstract = {{<p>Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types. Methods: Patients with Caucasian skin types (Fitzpatrick I-II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used to demonstrate the sensitivity (SE) and specificity (SP) in comparison with the re-evaluated histopathology diagnoses. Results: In 186 patients, 202 pigmented skin lesions were included. The sensitivity to detect cMM was 96.7% (87/90), and the specificity for benign lesions was 42.1% (45/107). The AUC was 0.800 (95% confidence interval (CI): 0.740-0.861). Conclusions: Our novel HSI device showed a high sensitivity in detecting malignant lesions in patients with Caucasian skin types. Compared with analogous technologies, as multispectral imaging or electrical impedance spectroscopy, our device showed similar or better accuracy in differentiating cMM from benign PSLs. Therefore, it might be a useful clinical tool in skin types I-IV and where further triage of pigmented skin lesions is important.</p>}}, author = {{Christensen, Gustav Boelsgaard and Nagaoka, Takashi and Kiyohara, Yoshio and Johansson, Iva and Ingvar, Christian and Nakamura, Atsushi and Sota, Takayuki and Nielsen, Kari}}, issn = {{0909-752X}}, keywords = {{Caucasian skin type; hyperspectral imaging; melanoma; pigmented skin lesions}}, language = {{eng}}, publisher = {{Wiley-Blackwell}}, series = {{Skin Research and Technology}}, title = {{Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin}}, url = {{http://dx.doi.org/10.1111/srt.13023}}, doi = {{10.1111/srt.13023}}, year = {{2021}}, }