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The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis

Hillarp, Andreas LU ; Zöller, Bengt LU orcid ; Svensson, Peter LU and Dahlbäck, Björn LU (1997) In Thrombosis and Haemostasis 78(3). p.2-990
Abstract

A dimorphism in the 3'-untranslated region of the prothrombin gene (G to A transition at position 20210) has recently been reported to be associated with increases in plasma prothrombin levels and in the risk of venous thrombosis. We have examined the prothrombin dimorphism among 99 unselected outpatients with phlebography verified deep venous thrombosis, and in 282 healthy controls. The prevalence of the 20210 A allele was 7.1% (7/99) in the patient group, and 1.8% (5/282) in the healthy control group (p = 0.0095). The relative risk of venous thrombosis was calculated to be 4.2 (95% CI, 1.3 to 13.6), and was still significant when adjustment was made for age, sex and the factor V:R506Q mutation causing APC resistance [odds ratio 3.8... (More)

A dimorphism in the 3'-untranslated region of the prothrombin gene (G to A transition at position 20210) has recently been reported to be associated with increases in plasma prothrombin levels and in the risk of venous thrombosis. We have examined the prothrombin dimorphism among 99 unselected outpatients with phlebography verified deep venous thrombosis, and in 282 healthy controls. The prevalence of the 20210 A allele was 7.1% (7/99) in the patient group, and 1.8% (5/282) in the healthy control group (p = 0.0095). The relative risk of venous thrombosis was calculated to be 4.2 (95% CI, 1.3 to 13.6), and was still significant when adjustment was made for age, sex and the factor V:R506Q mutation causing APC resistance [odds ratio 3.8 (95% CI, 1.1 to 13.2)]. As previously reported, 28% of the patients were carriers of the factor V:R506Q mutation. Thus, 34% (one patient carried both traits) of unselected patients with deep venous thrombosis were carriers of an inherited prothrombotic disorder. To sum up, our results confirm the 20210 A allele of the prothrombin gene to be an important risk factor for venous thrombosis.

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type
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publication status
published
subject
keywords
Adult, Aged, Aged, 80 and over, Alleles, Female, Gene Frequency, Humans, Male, Middle Aged, Outpatients, Phlebography, Protein C, Prothrombin, Risk Factors, Sweden, Thrombophlebitis, Journal Article, Research Support, Non-U.S. Gov't
in
Thrombosis and Haemostasis
volume
78
issue
3
pages
3 pages
publisher
Schattauer GmbH
external identifiers
  • pmid:9308741
  • scopus:0030845360
ISSN
0340-6245
language
English
LU publication?
yes
id
624deed9-e7b4-4067-a5c0-315cb32b3433
date added to LUP
2017-10-19 15:29:18
date last changed
2024-10-28 15:58:54
@misc{624deed9-e7b4-4067-a5c0-315cb32b3433,
  abstract     = {{<p>A dimorphism in the 3'-untranslated region of the prothrombin gene (G to A transition at position 20210) has recently been reported to be associated with increases in plasma prothrombin levels and in the risk of venous thrombosis. We have examined the prothrombin dimorphism among 99 unselected outpatients with phlebography verified deep venous thrombosis, and in 282 healthy controls. The prevalence of the 20210 A allele was 7.1% (7/99) in the patient group, and 1.8% (5/282) in the healthy control group (p = 0.0095). The relative risk of venous thrombosis was calculated to be 4.2 (95% CI, 1.3 to 13.6), and was still significant when adjustment was made for age, sex and the factor V:R506Q mutation causing APC resistance [odds ratio 3.8 (95% CI, 1.1 to 13.2)]. As previously reported, 28% of the patients were carriers of the factor V:R506Q mutation. Thus, 34% (one patient carried both traits) of unselected patients with deep venous thrombosis were carriers of an inherited prothrombotic disorder. To sum up, our results confirm the 20210 A allele of the prothrombin gene to be an important risk factor for venous thrombosis.</p>}},
  author       = {{Hillarp, Andreas and Zöller, Bengt and Svensson, Peter and Dahlbäck, Björn}},
  issn         = {{0340-6245}},
  keywords     = {{Adult; Aged; Aged, 80 and over; Alleles; Female; Gene Frequency; Humans; Male; Middle Aged; Outpatients; Phlebography; Protein C; Prothrombin; Risk Factors; Sweden; Thrombophlebitis; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{2--990}},
  publisher    = {{Schattauer GmbH}},
  series       = {{Thrombosis and Haemostasis}},
  title        = {{The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis}},
  volume       = {{78}},
  year         = {{1997}},
}