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Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients

Englund, Emma LU ; Maxedius, Annica LU ; Odermarsky, Michal LU and Liuba, Petru LU (2018) 52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology In Cardiology in the Young 28(S1). p.43-44
Abstract (Swedish)
Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.
Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.
Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index... (More)
Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.
Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.
Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.
Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p>0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p<0.05 for both) and HDL-C was decreased (p<0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).
Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiology in the Young
volume
28
issue
S1
pages
43 - 44
publisher
Cambridge University Press
conference name
52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology
conference location
Athens, Greece
conference dates
2018-05-09 - 2018-05-12
ISSN
1467-1107
DOI
10.1017/S1047951118000318
language
English
LU publication?
yes
id
6255e459-8fcc-46d0-a460-4291149361a2
date added to LUP
2018-05-13 20:17:58
date last changed
2018-11-21 21:39:48
@misc{6255e459-8fcc-46d0-a460-4291149361a2,
  abstract     = {Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.<br>
Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.<br>
Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.<br>
Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p&gt;0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p&lt;0.05 for both) and HDL-C was decreased (p&lt;0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).<br>
Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way.},
  articleno    = {MP1-8},
  author       = {Englund, Emma and Maxedius, Annica and Odermarsky, Michal and Liuba, Petru},
  issn         = {1467-1107},
  language     = {eng},
  location     = {Athens, Greece},
  note         = {Conference Abstract},
  number       = {S1},
  pages        = {43--44},
  publisher    = {Cambridge University Press},
  series       = {Cardiology in the Young},
  title        = {Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients},
  url          = {http://dx.doi.org/10.1017/S1047951118000318},
  volume       = {28},
  year         = {2018},
}