90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy.
(2010) In Journal of Nuclear Medicine 51(12). p.1974-1978- Abstract
- This feasibility study demonstrates (90)Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative (90)Y-ibritumomab treatment. METHODS: The study includes pretherapy (111)In SPECT/CT and planar whole-body (WB) imaging at 7 d and therapy (90)Y SPECT/CT at 6 d and (90)Y WB imaging at 1 d. Time-activity curves and organ-absorbed doses derived from (90)Y SPECT images were compared with pretherapy (111)In estimates. Organ activities derived from (90)Y WB images at the first day were compared with corresponding pretherapy estimates. RESULTS: Pretherapy (111)In images from 3 patients were similar to the (90)Y images. Differences between absorbed-dose estimates from pretherapy (111)In and (90)Y therapy were within 25%,... (More)
- This feasibility study demonstrates (90)Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative (90)Y-ibritumomab treatment. METHODS: The study includes pretherapy (111)In SPECT/CT and planar whole-body (WB) imaging at 7 d and therapy (90)Y SPECT/CT at 6 d and (90)Y WB imaging at 1 d. Time-activity curves and organ-absorbed doses derived from (90)Y SPECT images were compared with pretherapy (111)In estimates. Organ activities derived from (90)Y WB images at the first day were compared with corresponding pretherapy estimates. RESULTS: Pretherapy (111)In images from 3 patients were similar to the (90)Y images. Differences between absorbed-dose estimates from pretherapy (111)In and (90)Y therapy were within 25%, except for the lungs. Corresponding activity differences derived from WB images were within 25%. Differences were ascribed to incomplete compensation methods and real differences in pharmacokinetics between pretherapy and therapy. CONCLUSION: Quantitative bremsstrahlung imaging to estimate organ activities and absorbed doses is feasible. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731954
- author
- Minarik, David LU ; Sjögreen Gleisner, Katarina LU ; Lindén, Ola LU ; Wingårdh, Karin LU ; Tennvall, Jan LU ; Strand, Sven-Erik LU and Ljungberg, Michael LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- quantification, activity, radioimmunotherapy, imaging, yttrium, bremsstrahlung
- in
- Journal of Nuclear Medicine
- volume
- 51
- issue
- 12
- pages
- 1974 - 1978
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- wos:000284530300041
- pmid:21078799
- scopus:78651289412
- pmid:21078799
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.110.079897
- language
- English
- LU publication?
- yes
- id
- 62ce53a8-6835-4b8a-a816-f7a86d5ed8d7 (old id 1731954)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21078799?dopt=Abstract
- date added to LUP
- 2016-04-01 14:29:53
- date last changed
- 2022-02-27 02:55:55
@article{62ce53a8-6835-4b8a-a816-f7a86d5ed8d7, abstract = {{This feasibility study demonstrates (90)Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative (90)Y-ibritumomab treatment. METHODS: The study includes pretherapy (111)In SPECT/CT and planar whole-body (WB) imaging at 7 d and therapy (90)Y SPECT/CT at 6 d and (90)Y WB imaging at 1 d. Time-activity curves and organ-absorbed doses derived from (90)Y SPECT images were compared with pretherapy (111)In estimates. Organ activities derived from (90)Y WB images at the first day were compared with corresponding pretherapy estimates. RESULTS: Pretherapy (111)In images from 3 patients were similar to the (90)Y images. Differences between absorbed-dose estimates from pretherapy (111)In and (90)Y therapy were within 25%, except for the lungs. Corresponding activity differences derived from WB images were within 25%. Differences were ascribed to incomplete compensation methods and real differences in pharmacokinetics between pretherapy and therapy. CONCLUSION: Quantitative bremsstrahlung imaging to estimate organ activities and absorbed doses is feasible.}}, author = {{Minarik, David and Sjögreen Gleisner, Katarina and Lindén, Ola and Wingårdh, Karin and Tennvall, Jan and Strand, Sven-Erik and Ljungberg, Michael}}, issn = {{0161-5505}}, keywords = {{quantification; activity; radioimmunotherapy; imaging; yttrium; bremsstrahlung}}, language = {{eng}}, number = {{12}}, pages = {{1974--1978}}, publisher = {{Society of Nuclear Medicine}}, series = {{Journal of Nuclear Medicine}}, title = {{90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy.}}, url = {{http://dx.doi.org/10.2967/jnumed.110.079897}}, doi = {{10.2967/jnumed.110.079897}}, volume = {{51}}, year = {{2010}}, }