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How to avoid severe coronary vasoconstriction in potassium induced cardioplegia

Qin, Guangqi LU ; Chen, Liwei; Sjöberg, Trygve LU and Steen, Stig LU (2018) In Scandinavian Cardiovascular Journal 52(6). p.344-347
Abstract

Objectives. The aim of this study was to investigate how high K+ concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction. Design. Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O2 and 5% CO2. K+ concentrations between 16 and 127 mM were used to induce vasocontractions at 37, 22, 15, and 8 °C. Mg2+ (0–20 mM) were used to attenuate K+ induced vasocontractions. Results. K+-Krebs solution 127 mM at 37 °C induced a strong, sustained vasocontraction defined as... (More)

Objectives. The aim of this study was to investigate how high K+ concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction. Design. Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O2 and 5% CO2. K+ concentrations between 16 and 127 mM were used to induce vasocontractions at 37, 22, 15, and 8 °C. Mg2+ (0–20 mM) were used to attenuate K+ induced vasocontractions. Results. K+-Krebs solution 127 mM at 37 °C induced a strong, sustained vasocontraction defined as 100%. The contractions induced by 16, 23, 30 and 127 mM K+ were: 7.7, 38, 72 and 100% at 37 °C; 1.7, 7.4, 21 and 65% at 22 °C; 1, 6.6, 15 and 33% at 15 °C; 0.6, 2.1, 6 and 14% at 8 °C, respectively. Mg2+ reduced the K+-induced contraction at 37 °C in a concentration-dependent way and Mg2+ at 8 mM practically eliminated the risk for severe vasocontraction. Conclusions. Hypothermia (8 °C) abolishes coronary contraction induced by K+-cardioplegic solutions. In normothermic cardioplegia 8 mM Mg2+ prevents vasoconstriction.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardioplegic solution, Coronary artery contraction, magnesium, potassium, temperature
in
Scandinavian Cardiovascular Journal
volume
52
issue
6
pages
344 - 347
publisher
Taylor & Francis
external identifiers
  • scopus:85059895128
ISSN
1401-7431
DOI
10.1080/14017431.2018.1552794
language
English
LU publication?
yes
id
632580b1-c35b-4aea-89fc-fd908d167329
date added to LUP
2019-01-24 09:54:30
date last changed
2019-06-28 01:49:41
@article{632580b1-c35b-4aea-89fc-fd908d167329,
  abstract     = {<p>Objectives. The aim of this study was to investigate how high K<sup>+</sup> concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction. Design. Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O<sub>2</sub> and 5% CO<sub>2</sub>. K<sup>+</sup> concentrations between 16 and 127 mM were used to induce vasocontractions at 37, 22, 15, and 8 °C. Mg<sup>2+</sup> (0–20 mM) were used to attenuate K<sup>+</sup> induced vasocontractions. Results. K<sup>+</sup>-Krebs solution 127 mM at 37 °C induced a strong, sustained vasocontraction defined as 100%. The contractions induced by 16, 23, 30 and 127 mM K<sup>+</sup> were: 7.7, 38, 72 and 100% at 37 °C; 1.7, 7.4, 21 and 65% at 22 °C; 1, 6.6, 15 and 33% at 15 °C; 0.6, 2.1, 6 and 14% at 8 °C, respectively. Mg<sup>2+</sup> reduced the K<sup>+</sup>-induced contraction at 37 °C in a concentration-dependent way and Mg<sup>2+</sup> at 8 mM practically eliminated the risk for severe vasocontraction. Conclusions. Hypothermia (8 °C) abolishes coronary contraction induced by K<sup>+</sup>-cardioplegic solutions. In normothermic cardioplegia 8 mM Mg<sup>2+</sup> prevents vasoconstriction.</p>},
  author       = {Qin, Guangqi and Chen, Liwei and Sjöberg, Trygve and Steen, Stig},
  issn         = {1401-7431},
  keyword      = {cardioplegic solution,Coronary artery contraction,magnesium,potassium,temperature},
  language     = {eng},
  number       = {6},
  pages        = {344--347},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {How to avoid severe coronary vasoconstriction in potassium induced cardioplegia},
  url          = {http://dx.doi.org/10.1080/14017431.2018.1552794},
  volume       = {52},
  year         = {2018},
}