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Synthesis and characterisation of novel platinum-based drug candidates

Bjelosevic, Haris LU ; Sykfont Snygg, Åse LU ; Spegel, Christer LU ; Gorton, Lo LU ; Elmroth, Sofi LU and Persson, Tina LU (2006) 37th International Coordination Chemistry Conference (ICCC)
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author
; ; ; ; and
organization
publishing date
type
Contribution to conference
publication status
published
subject
keywords
dppf, cv, ferrocene, platinum, phosphine, Pt, amino acids, oligonucleotides, bindning, uridine, kinetics
conference name
37th International Coordination Chemistry Conference (ICCC)
conference location
Cape Town, South Africa
conference dates
2006-08-13 - 2006-08-18
language
English
LU publication?
yes
additional info
Abstract: One of the most widely used anticancer drugs is cisplatin, (cis-diaminodichloroplatinum(II)). Despite its clinical success, cisplatin still suffers from a number of problems, like generating resistance and high toxicity due to poor selectivity. By molecular design, we are searching for new platinum complexes with different properties and trying to understand their cellular behaviour. We have synthesised derivatives of 1,1’-bis(diphenylphosphino)-ferrocene (dppf) and their corresponding cis-platinum complexes. These compounds have been tested for their interaction capacity with respect to L-cys, L-met and different oligonucleotides. Comparative kinetic studies reveal that substituents have a significant effect upon the reaction kinetics. The substituted complexes were found to have an increased reactivity. Even compared to cisplatin, the reactivity of dppf containing complexes was found to be significantly enhanced. The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Biochemistry and Structural Biology (S) (000006142), Analytical Chemistry (S/LTH) (011001004)
id
0d3cc812-ee42-47d9-a4b7-44ff9a7a0eeb (old id 633024)
date added to LUP
2016-04-04 13:18:34
date last changed
2018-11-21 21:13:08
@misc{0d3cc812-ee42-47d9-a4b7-44ff9a7a0eeb,
  author       = {Bjelosevic, Haris and Sykfont Snygg, Åse and Spegel, Christer and Gorton, Lo and Elmroth, Sofi and Persson, Tina},
  language     = {eng},
  title        = {Synthesis and characterisation of novel platinum-based drug candidates},
  url          = {https://lup.lub.lu.se/search/files/6088544/633041.pdf},
  year         = {2006},
}