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Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity

Hellgren, Gunnel ; Löfqvist, Chatarina ; Hansen-Pupp, Ingrid LU orcid ; Gram, Magnus LU orcid ; Smith, Lois E. ; Ley, David LU and Hellström, Ann LU (2018) In Growth Hormone and IGF Research 39. p.19-24
Abstract

Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up... (More)

Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up to 13. weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. Results: IL-6 levels negatively correlated with IGF-I levels between 5 and 8. weeks after birth, (p <. 0.01 to p <. 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p <. 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. Conclusions: The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IGF-I, Pro-inflammatory cytokines, Retinopathy of prematurity
in
Growth Hormone and IGF Research
volume
39
pages
19 - 24
publisher
Elsevier
external identifiers
  • pmid:29274846
  • scopus:85038959326
ISSN
1096-6374
DOI
10.1016/j.ghir.2017.11.006
language
English
LU publication?
yes
id
6351c439-0051-4ab0-bb80-b9afd2d1dd10
date added to LUP
2018-01-23 13:39:00
date last changed
2024-04-15 02:12:01
@article{6351c439-0051-4ab0-bb80-b9afd2d1dd10,
  abstract     = {{<p>Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up to 13. weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. Results: IL-6 levels negatively correlated with IGF-I levels between 5 and 8. weeks after birth, (p &lt;. 0.01 to p &lt;. 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p &lt;. 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. Conclusions: The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.</p>}},
  author       = {{Hellgren, Gunnel and Löfqvist, Chatarina and Hansen-Pupp, Ingrid and Gram, Magnus and Smith, Lois E. and Ley, David and Hellström, Ann}},
  issn         = {{1096-6374}},
  keywords     = {{IGF-I; Pro-inflammatory cytokines; Retinopathy of prematurity}},
  language     = {{eng}},
  pages        = {{19--24}},
  publisher    = {{Elsevier}},
  series       = {{Growth Hormone and IGF Research}},
  title        = {{Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity}},
  url          = {{http://dx.doi.org/10.1016/j.ghir.2017.11.006}},
  doi          = {{10.1016/j.ghir.2017.11.006}},
  volume       = {{39}},
  year         = {{2018}},
}