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Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity

Hellgren, Gunnel; Löfqvist, Chatarina; Hansen-Pupp, Ingrid LU ; Gram, Magnus LU ; Smith, Lois E.; Ley, David LU and Hellström, Ann LU (2017) In Growth Hormone and IGF Research
Abstract

Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up... (More)

Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up to 13. weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. Results: IL-6 levels negatively correlated with IGF-I levels between 5 and 8. weeks after birth, (p <. 0.01 to p <. 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p <. 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. Conclusions: The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
IGF-I, Pro-inflammatory cytokines, Retinopathy of prematurity
in
Growth Hormone and IGF Research
publisher
Elsevier
external identifiers
  • scopus:85038959326
ISSN
1096-6374
DOI
10.1016/j.ghir.2017.11.006
language
English
LU publication?
yes
id
6351c439-0051-4ab0-bb80-b9afd2d1dd10
date added to LUP
2018-01-23 13:39:00
date last changed
2018-01-24 03:00:02
@article{6351c439-0051-4ab0-bb80-b9afd2d1dd10,
  abstract     = {<p>Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24. h after birth, and then weekly until at least 36. weeks postmenstrual age (PMA) (i.e., up to 13. weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. Results: IL-6 levels negatively correlated with IGF-I levels between 5 and 8. weeks after birth, (p &lt;. 0.01 to p &lt;. 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p &lt;. 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. Conclusions: The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.</p>},
  author       = {Hellgren, Gunnel and Löfqvist, Chatarina and Hansen-Pupp, Ingrid and Gram, Magnus and Smith, Lois E. and Ley, David and Hellström, Ann},
  issn         = {1096-6374},
  keyword      = {IGF-I,Pro-inflammatory cytokines,Retinopathy of prematurity},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {Growth Hormone and IGF Research},
  title        = {Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity},
  url          = {http://dx.doi.org/10.1016/j.ghir.2017.11.006},
  year         = {2017},
}