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Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae

Almeida, Joao LU ; Modig, Tobias LU ; Petersson, Anneli; Hahn-Hägerdal, Bärbel LU ; Lidén, Gunnar LU and Gorwa-Grauslund, Marie-Francoise LU (2007) In Journal of Chemical Technology and Biotechnology 82(4). p.340-349
Abstract
During hydrolysis of lignocellulosic biomass, monomeric sugars and a broad range of inhibitory compounds are formed and released. These inhibitors, which can be organized around three main groups, furans, weak acids and phenolics, reduce ethanol yield and productivity by affecting the microorganism performance during the fermentation step. Among the microorganisms that have been evaluated for lignocellulosic hydrolysate ethanol fermentation, the yeast Saccharomyces cerevisiae appears to be the least sensitive. In order to overcome the effect of inhibitors, strategies that include improvement of natural tolerance of microorganism and use of fermentation control strategies have been developed. An overview of the origin, effects and... (More)
During hydrolysis of lignocellulosic biomass, monomeric sugars and a broad range of inhibitory compounds are formed and released. These inhibitors, which can be organized around three main groups, furans, weak acids and phenolics, reduce ethanol yield and productivity by affecting the microorganism performance during the fermentation step. Among the microorganisms that have been evaluated for lignocellulosic hydrolysate ethanol fermentation, the yeast Saccharomyces cerevisiae appears to be the least sensitive. In order to overcome the effect of inhibitors, strategies that include improvement of natural tolerance of microorganism and use of fermentation control strategies have been developed. An overview of the origin, effects and mechanisms of action of known inhibitors on S. cerevisiae is given. Fermentation control strategies as well as metabolic, genetic and evolutionary engineering strategies to obtain S. cerevisiae strains with improved tolerance are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
weak acids, furans, phenolics, lignocellulose, inhibitor, tolerance, Saccharomyces cerevisiae
in
Journal of Chemical Technology and Biotechnology
volume
82
issue
4
pages
340 - 349
publisher
Wiley-Blackwell
external identifiers
  • wos:000245967900003
  • scopus:33947286326
ISSN
0268-2575
DOI
10.1002/jctb.1676
language
English
LU publication?
yes
id
b4f24b7c-6e2c-45f1-856e-5a3e43e73789 (old id 636689)
date added to LUP
2007-11-29 16:26:56
date last changed
2017-11-19 04:11:45
@article{b4f24b7c-6e2c-45f1-856e-5a3e43e73789,
  abstract     = {During hydrolysis of lignocellulosic biomass, monomeric sugars and a broad range of inhibitory compounds are formed and released. These inhibitors, which can be organized around three main groups, furans, weak acids and phenolics, reduce ethanol yield and productivity by affecting the microorganism performance during the fermentation step. Among the microorganisms that have been evaluated for lignocellulosic hydrolysate ethanol fermentation, the yeast Saccharomyces cerevisiae appears to be the least sensitive. In order to overcome the effect of inhibitors, strategies that include improvement of natural tolerance of microorganism and use of fermentation control strategies have been developed. An overview of the origin, effects and mechanisms of action of known inhibitors on S. cerevisiae is given. Fermentation control strategies as well as metabolic, genetic and evolutionary engineering strategies to obtain S. cerevisiae strains with improved tolerance are discussed.},
  author       = {Almeida, Joao and Modig, Tobias and Petersson, Anneli and Hahn-Hägerdal, Bärbel and Lidén, Gunnar and Gorwa-Grauslund, Marie-Francoise},
  issn         = {0268-2575},
  keyword      = {weak acids,furans,phenolics,lignocellulose,inhibitor,tolerance,Saccharomyces cerevisiae},
  language     = {eng},
  number       = {4},
  pages        = {340--349},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Chemical Technology and Biotechnology},
  title        = {Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae},
  url          = {http://dx.doi.org/10.1002/jctb.1676},
  volume       = {82},
  year         = {2007},
}