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Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case

Dahlin, Lars B. LU orcid ; Scherman, Peter LU ; Besjakov, Jack LU ; Lindberg, Eva ; Solomon, David A. ; Horvai, Andrew E. and Perry, Arie (2017) In Clinical Neuropathology 36(7). p.164-170
Abstract

A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large... (More)

A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BRAF mutation, CT-PET, Intraneural glomus tumor, Median nerve, MRI, Uncertain malignancy
in
Clinical Neuropathology
volume
36
issue
7
pages
7 pages
publisher
Dustri-Verlag
external identifiers
  • pmid:28438258
  • wos:000405023600003
  • scopus:85021993618
ISSN
0722-5091
DOI
10.5414/NP300989
language
English
LU publication?
yes
id
638425e3-b266-4f47-9658-98d2aa2efa62
date added to LUP
2017-08-22 10:47:25
date last changed
2025-01-07 19:04:04
@article{638425e3-b266-4f47-9658-98d2aa2efa62,
  abstract     = {{<p>A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis.</p>}},
  author       = {{Dahlin, Lars B. and Scherman, Peter and Besjakov, Jack and Lindberg, Eva and Solomon, David A. and Horvai, Andrew E. and Perry, Arie}},
  issn         = {{0722-5091}},
  keywords     = {{BRAF mutation; CT-PET; Intraneural glomus tumor; Median nerve; MRI; Uncertain malignancy}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{164--170}},
  publisher    = {{Dustri-Verlag}},
  series       = {{Clinical Neuropathology}},
  title        = {{Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case}},
  url          = {{http://dx.doi.org/10.5414/NP300989}},
  doi          = {{10.5414/NP300989}},
  volume       = {{36}},
  year         = {{2017}},
}