Computational design of protein self-assembly
Norn, Christoffer H. LU and André, Ingemar LU
(2016)
In Current Opinion in Structural Biology
39.
p.39-45
- Abstract
Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/638ab7fc-58f8-485b-bdf2-1c55f8f9e947
- author
- Norn, Christoffer H.
LU
and André, Ingemar
LU
- organization
- publishing date
- 2016-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Structural Biology
- volume
- 39
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84973131364
- pmid:27127996
- wos:000386411000007
- ISSN
- 0959-440X
- DOI
- 10.1016/j.sbi.2016.04.002
- language
- English
- LU publication?
- yes
- id
- 638ab7fc-58f8-485b-bdf2-1c55f8f9e947
- date added to LUP
- 2016-06-23 07:40:44
- date last changed
- 2024-03-07 08:30:26
@article{638ab7fc-58f8-485b-bdf2-1c55f8f9e947,
abstract = {{<p>Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.</p>}},
author = {{Norn, Christoffer H. and André, Ingemar}},
issn = {{0959-440X}},
language = {{eng}},
month = {{08}},
pages = {{39--45}},
publisher = {{Elsevier}},
series = {{Current Opinion in Structural Biology}},
title = {{Computational design of protein self-assembly}},
url = {{http://dx.doi.org/10.1016/j.sbi.2016.04.002}},
doi = {{10.1016/j.sbi.2016.04.002}},
volume = {{39}},
year = {{2016}},
}