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Parkinson's Disease among Immigrant Groups and Swedish-Born Individuals : A Cohort Study of All Adults 50 Years of Age and Older in Sweden

Wändell, Per LU ; Fredrikson, Sten ; Carlsson, Axel C. ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2020) In Journal of Parkinson's Disease 10(3). p.1133-1141
Abstract

Background: There is a lack of studies of Parkinson's disease (PD) in immigrants. Objective: To study the association between country of birth and incident PD in immigrants in Sweden versus Swedish-born individuals. Methods: Study population included all adults aged 50 years and older in Sweden (n=2775736). PD was defined as having at least one registered diagnosis of PD in the National Patient Register. The incidence of PD in different first-generation immigrant groups versus Swedish-born individuals was assessed by Cox regression, expressed as hazard ratios (HRs) and 95% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, neighbourhood... (More)

Background: There is a lack of studies of Parkinson's disease (PD) in immigrants. Objective: To study the association between country of birth and incident PD in immigrants in Sweden versus Swedish-born individuals. Methods: Study population included all adults aged 50 years and older in Sweden (n=2775736). PD was defined as having at least one registered diagnosis of PD in the National Patient Register. The incidence of PD in different first-generation immigrant groups versus Swedish-born individuals was assessed by Cox regression, expressed as hazard ratios (HRs) and 95% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, neighbourhood socioeconomic status and co-morbidity. Results: Totally 35833 individuals had an incident diagnosis of PD (20401 men and 15432 women). Incidence rates per 100,000 person-years were for all Swedish-born 95.9 and for all foreign-born 60.1; for all men 112.3 and for all women 73.4, with a male to female ratio of 1.53, with the highest incidence rates for the group 80-84 years of age. After adjusting for potential confounders, the overall relative risk of PD was lower in immigrant men (HR 0.78; 95% CI 0.74-0.82) and women (HR 0.92; 95% CI 0.87-0.98). Among immigrant subgroups, a higher risk of PD was found among women from Finland (HR 1.13; 95% CI 1.05-1.23). Conclusion: In general, the risk of PD was lower in first-generation immigrant men and women compared to Swedish-born. The only group with a higher risk of PD was women from Finland.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gender, immigrants, neighborhood, Parkinson's disease, socioeconomic status
in
Journal of Parkinson's Disease
volume
10
issue
3
pages
9 pages
publisher
IOS Press
external identifiers
  • scopus:85089129745
  • pmid:32568106
ISSN
1877-7171
DOI
10.3233/JPD-201962
language
English
LU publication?
yes
id
63a19e68-7ef8-4214-b01f-560cac44b1b4
date added to LUP
2020-08-20 08:33:14
date last changed
2021-06-16 06:15:16
@article{63a19e68-7ef8-4214-b01f-560cac44b1b4,
  abstract     = {<p>Background: There is a lack of studies of Parkinson's disease (PD) in immigrants. Objective: To study the association between country of birth and incident PD in immigrants in Sweden versus Swedish-born individuals. Methods: Study population included all adults aged 50 years and older in Sweden (n=2775736). PD was defined as having at least one registered diagnosis of PD in the National Patient Register. The incidence of PD in different first-generation immigrant groups versus Swedish-born individuals was assessed by Cox regression, expressed as hazard ratios (HRs) and 95% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, neighbourhood socioeconomic status and co-morbidity. Results: Totally 35833 individuals had an incident diagnosis of PD (20401 men and 15432 women). Incidence rates per 100,000 person-years were for all Swedish-born 95.9 and for all foreign-born 60.1; for all men 112.3 and for all women 73.4, with a male to female ratio of 1.53, with the highest incidence rates for the group 80-84 years of age. After adjusting for potential confounders, the overall relative risk of PD was lower in immigrant men (HR 0.78; 95% CI 0.74-0.82) and women (HR 0.92; 95% CI 0.87-0.98). Among immigrant subgroups, a higher risk of PD was found among women from Finland (HR 1.13; 95% CI 1.05-1.23). Conclusion: In general, the risk of PD was lower in first-generation immigrant men and women compared to Swedish-born. The only group with a higher risk of PD was women from Finland.</p>},
  author       = {Wändell, Per and Fredrikson, Sten and Carlsson, Axel C. and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1877-7171},
  language     = {eng},
  number       = {3},
  pages        = {1133--1141},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Parkinson's Disease among Immigrant Groups and Swedish-Born Individuals : A Cohort Study of All Adults 50 Years of Age and Older in Sweden},
  url          = {http://dx.doi.org/10.3233/JPD-201962},
  doi          = {10.3233/JPD-201962},
  volume       = {10},
  year         = {2020},
}