A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function : a substudy of the PREDIMED-Plus randomized controlled trial
(2021) In The American journal of clinical nutrition 114(5). p.1666-1674- Abstract
BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. METHODS: In 391 older adults with metabolic syndrome (mean age, 65 years; mean BMI, 33.3 kg/m2) from 1 of the Prevención con Dieta Mediterránea-Plus trial centers, we evaluated the impact of a... (More)
BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. METHODS: In 391 older adults with metabolic syndrome (mean age, 65 years; mean BMI, 33.3 kg/m2) from 1 of the Prevención con Dieta Mediterránea-Plus trial centers, we evaluated the impact of a 6-month intervention with an energy-restricted Mediterranean diet plus physical activity (intensive lifestyle; n = 190) relative to a nonrestrictive Mediterranean diet without physical activity (control; n = 201) on a set of HDL functional traits. These included cholesterol efflux capacity, HDL oxidative/inflammatory index, HDL oxidation, and levels of complement component 3, serum amyloid A, sphingosine-1-phosphate, triglycerides, and apolipoproteins A-I, A-IV, C-III, and E in apoB-depleted plasma. RESULTS: The intensive-lifestyle intervention participants displayed greater 6-month weight reductions (-3.83 kg; 95% CI: -4.57 to -3.09 kg) but no changes in HDL cholesterol compared with control-diet participants. Regarding HDL functional traits, the intensive lifestyle decreased triglyceride levels (-0.15 mg/g protein; 95% CI: -0.29 to -0.014 mg/g protein) and apoC-III (-0.11 mg/g protein; 95% CI: -0.18 to -0.026 mg/g protein) compared to the control diet, with weight loss being the essential mediator (proportions of mediation were 77.4% and 72.1% for triglycerides and apoC-III levels in HDL, respectively). CONCLUSIONS: In older adults with metabolic syndrome, an energy-restricted Mediterranean diet plus physical activity improved the HDL triglyceride metabolism compared with a nonrestrictive Mediterranean diet without physical activity. This trial is registered at isrctn.com as ISRCTN89898870.
(Less)
- author
- organization
- publishing date
- 2021-11-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- calorie restriction, high-density lipoprotein, Mediterranean diet, physical activity, randomized controlled trial
- in
- The American journal of clinical nutrition
- volume
- 114
- issue
- 5
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:34582548
- scopus:85121947440
- ISSN
- 1938-3207
- DOI
- 10.1093/ajcn/nqab246
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
- id
- 63e387f8-6cbe-4bad-92a1-582ac6a90b50
- date added to LUP
- 2022-02-21 11:09:48
- date last changed
- 2024-04-18 05:45:28
@article{63e387f8-6cbe-4bad-92a1-582ac6a90b50,
abstract = {{<p>BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. METHODS: In 391 older adults with metabolic syndrome (mean age, 65 years; mean BMI, 33.3 kg/m2) from 1 of the Prevención con Dieta Mediterránea-Plus trial centers, we evaluated the impact of a 6-month intervention with an energy-restricted Mediterranean diet plus physical activity (intensive lifestyle; n = 190) relative to a nonrestrictive Mediterranean diet without physical activity (control; n = 201) on a set of HDL functional traits. These included cholesterol efflux capacity, HDL oxidative/inflammatory index, HDL oxidation, and levels of complement component 3, serum amyloid A, sphingosine-1-phosphate, triglycerides, and apolipoproteins A-I, A-IV, C-III, and E in apoB-depleted plasma. RESULTS: The intensive-lifestyle intervention participants displayed greater 6-month weight reductions (-3.83 kg; 95% CI: -4.57 to -3.09 kg) but no changes in HDL cholesterol compared with control-diet participants. Regarding HDL functional traits, the intensive lifestyle decreased triglyceride levels (-0.15 mg/g protein; 95% CI: -0.29 to -0.014 mg/g protein) and apoC-III (-0.11 mg/g protein; 95% CI: -0.18 to -0.026 mg/g protein) compared to the control diet, with weight loss being the essential mediator (proportions of mediation were 77.4% and 72.1% for triglycerides and apoC-III levels in HDL, respectively). CONCLUSIONS: In older adults with metabolic syndrome, an energy-restricted Mediterranean diet plus physical activity improved the HDL triglyceride metabolism compared with a nonrestrictive Mediterranean diet without physical activity. This trial is registered at isrctn.com as ISRCTN89898870.</p>}},
author = {{Sanllorente, Albert and Soria-Florido, María Trinidad and Castañer, Olga and Lassale, Camille and Salas-Salvadó, Jordi and Martínez-González, Miguel Ángel and Subirana, Isaac and Ros, Emilio and Corella, Dolores and Estruch, Ramón and Tinahones, Francisco J. and Hernáez, Álvaro and Fitó, Montserrat}},
issn = {{1938-3207}},
keywords = {{calorie restriction; high-density lipoprotein; Mediterranean diet; physical activity; randomized controlled trial}},
language = {{eng}},
month = {{11}},
number = {{5}},
pages = {{1666--1674}},
publisher = {{Oxford University Press}},
series = {{The American journal of clinical nutrition}},
title = {{A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function : a substudy of the PREDIMED-Plus randomized controlled trial}},
url = {{http://dx.doi.org/10.1093/ajcn/nqab246}},
doi = {{10.1093/ajcn/nqab246}},
volume = {{114}},
year = {{2021}},
}