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Renal function and its association with blood pressure in Middle Eastern immigrants and native Swedes

Nilsson, Christopher LU ; Christensson, Anders LU ; Nilsson, Peter M. LU and Bennet, Louise LU (2017) In Journal of Hypertension
Abstract

BACKGROUND:: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. METHODS:: A population-based, cross-sectional study of men and women, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. Blood samples were drawn, physical examinations performed and self-administrated questionnaires were assessed. Estimated... (More)

BACKGROUND:: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. METHODS:: A population-based, cross-sectional study of men and women, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. Blood samples were drawn, physical examinations performed and self-administrated questionnaires were assessed. Estimated glomerular filtration rate (eGFR) was calculated from the Caucasian Asian Pediatric Adult cohort formula based on cystatin C. RESULTS:: Participants without history of cardiovascular disease born in Iraq (n?=?1214), irrespective of age and sex, presented with higher eGFR than participants born in Sweden (n?=?659), (96.5?ml/min per 1.73?m vs. 93.6, P?=?0.009). Furthermore, eGFR showed weaker association with BP in Iraqis than in Swedes, especially for SBP. The relationship was confirmed by a significant interaction between eGFR and country of birth (Pinteraction country of birth?×?eGFRcystatinC?=?0.004). CONCLUSION:: The current study shows differences across ethnicities in renal function and its associations with BP. More studies are needed to understand mechanisms contributing to BP regulation and renal function in populations of different ethnic backgrounds.

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author
organization
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Contribution to journal
publication status
epub
in
Journal of Hypertension
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85025462018
ISSN
0263-6352
DOI
10.1097/HJH.0000000000001490
language
English
LU publication?
yes
id
6416eca3-b5c5-4013-b3bd-8acb75be7578
date added to LUP
2017-08-25 15:51:37
date last changed
2017-08-26 03:00:03
@article{6416eca3-b5c5-4013-b3bd-8acb75be7578,
  abstract     = {<p>BACKGROUND:: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. METHODS:: A population-based, cross-sectional study of men and women, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. Blood samples were drawn, physical examinations performed and self-administrated questionnaires were assessed. Estimated glomerular filtration rate (eGFR) was calculated from the Caucasian Asian Pediatric Adult cohort formula based on cystatin C. RESULTS:: Participants without history of cardiovascular disease born in Iraq (n?=?1214), irrespective of age and sex, presented with higher eGFR than participants born in Sweden (n?=?659), (96.5?ml/min per 1.73?m vs. 93.6, P?=?0.009). Furthermore, eGFR showed weaker association with BP in Iraqis than in Swedes, especially for SBP. The relationship was confirmed by a significant interaction between eGFR and country of birth (Pinteraction country of birth?×?eGFRcystatinC?=?0.004). CONCLUSION:: The current study shows differences across ethnicities in renal function and its associations with BP. More studies are needed to understand mechanisms contributing to BP regulation and renal function in populations of different ethnic backgrounds.</p>},
  author       = {Nilsson, Christopher and Christensson, Anders and Nilsson, Peter M. and Bennet, Louise},
  issn         = {0263-6352},
  language     = {eng},
  month        = {07},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Renal function and its association with blood pressure in Middle Eastern immigrants and native Swedes},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000001490},
  year         = {2017},
}