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Improved in-plane visibility of tumors using breast tomosynthesis

Ruschin, Mark LU ; Timberg, Pontus LU ; Svahn, Tony LU ; Andersson, Ingvar LU ; Hemdal, Bengt LU ; Mattsson, Sören LU ; Båth, Magnus and Tingberg, Anders LU (2007) Medical Imaging 2007: Physics of Medical Imaging In Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6510(PART 1). p.514-524
Abstract
The purpose of this work was to evaluate and compare the visibility of simulated tumors in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the two systems, simulated, ellipsoid-shaped tumors (average dimension: 8.4 mm × 6.6 mm × 5 mm) with irregular margins were projected and added to each DM image as well as each BT projection image prior to 3D reconstruction. The same beam quality and approximately the same total absorbed dose were used for each breast image acquisition on both systems. Two simulated tumors were added to... (More)
The purpose of this work was to evaluate and compare the visibility of simulated tumors in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the two systems, simulated, ellipsoid-shaped tumors (average dimension: 8.4 mm × 6.6 mm × 5 mm) with irregular margins were projected and added to each DM image as well as each BT projection image prior to 3D reconstruction. The same beam quality and approximately the same total absorbed dose were used for each breast image acquisition on both systems. Two simulated tumors were added to each of thirty patient scans, yielding sixty cases. A series of 4-alternative forced choice (4-AFC) human observer experiments were conducted in order to determine what projected signal intensity (contrast) of the tumors in the DM images would be needed to achieve the same detectability as in the reconstructed BT images. Nine observers participated. For the BT 4-AFC experiment, when the signal intensity of the tumor on the central projection was 0.010 (natural logarithmic units) the mean percent of correct responses (PC) was measured to be 81.5%, which converted to a detectability index value (d') of 1.96. For the DM system, the same detectability was achieved at a signal intensity determined to be 0.038. Equivalent levels of tumor detection in BT images were thus achieved at around four times less projected signal intensity than in DM images, indicating that the use of BT may lead to earlier detection of breast cancer. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Digital breast tomosynthesis, Digital mammography, Signal intensity, Alternative forced choice
in
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume
6510
issue
PART 1
pages
514 - 524
publisher
SPIE
conference name
Medical Imaging 2007: Physics of Medical Imaging
external identifiers
  • wos:000247292100052
  • scopus:35148899751
ISSN
1605-7422
1042-4687
DOI
10.1117/12.707935
language
English
LU publication?
yes
id
62328bb3-7287-438e-9fe6-b48ca424c14c (old id 643207)
date added to LUP
2007-12-04 11:23:36
date last changed
2017-11-20 15:05:56
@inproceedings{62328bb3-7287-438e-9fe6-b48ca424c14c,
  abstract     = {The purpose of this work was to evaluate and compare the visibility of simulated tumors in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the two systems, simulated, ellipsoid-shaped tumors (average dimension: 8.4 mm × 6.6 mm × 5 mm) with irregular margins were projected and added to each DM image as well as each BT projection image prior to 3D reconstruction. The same beam quality and approximately the same total absorbed dose were used for each breast image acquisition on both systems. Two simulated tumors were added to each of thirty patient scans, yielding sixty cases. A series of 4-alternative forced choice (4-AFC) human observer experiments were conducted in order to determine what projected signal intensity (contrast) of the tumors in the DM images would be needed to achieve the same detectability as in the reconstructed BT images. Nine observers participated. For the BT 4-AFC experiment, when the signal intensity of the tumor on the central projection was 0.010 (natural logarithmic units) the mean percent of correct responses (PC) was measured to be 81.5%, which converted to a detectability index value (d') of 1.96. For the DM system, the same detectability was achieved at a signal intensity determined to be 0.038. Equivalent levels of tumor detection in BT images were thus achieved at around four times less projected signal intensity than in DM images, indicating that the use of BT may lead to earlier detection of breast cancer.},
  author       = {Ruschin, Mark and Timberg, Pontus and Svahn, Tony and Andersson, Ingvar and Hemdal, Bengt and Mattsson, Sören and Båth, Magnus and Tingberg, Anders},
  booktitle    = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
  issn         = {1605-7422},
  keyword      = {Digital breast tomosynthesis,Digital mammography,Signal intensity,Alternative forced choice},
  language     = {eng},
  number       = {PART 1},
  pages        = {514--524},
  publisher    = {SPIE},
  title        = {Improved in-plane visibility of tumors using breast tomosynthesis},
  url          = {http://dx.doi.org/10.1117/12.707935},
  volume       = {6510},
  year         = {2007},
}