Fibroblasts as architects of cancer pathogenesis
Marsh, Timothy ; Pietras, Kristian LU
and McAllister, Sandra S.
(2013)
In Biochimica et Biophysica Acta - Molecular Basis of Disease
1832(7).
p.1070-1078
- Abstract
- Studies of epithelial cancers (i.e., carcinomas) traditionally focused on transformation of the epithelium (i.e., the cancer cells) and how aberrant signaling within the cancer cells modulates the surrounding tissue of origin. In more recent decades, the normal cells, blood vessels, molecules, and extracellular components that surround the tumor cells, collectively known as the "tumor microenvironment" or "stroma", have received increasing attention and are now thought to be key regulators of tumor initiation and progression. Of particular relevance to the work reviewed herein are the fibroblasts, which make up the major cell type within the microenvironment of most carcinomas. Due to their inherent heterogeneity, plasticity, and function,... (More)
- Studies of epithelial cancers (i.e., carcinomas) traditionally focused on transformation of the epithelium (i.e., the cancer cells) and how aberrant signaling within the cancer cells modulates the surrounding tissue of origin. In more recent decades, the normal cells, blood vessels, molecules, and extracellular components that surround the tumor cells, collectively known as the "tumor microenvironment" or "stroma", have received increasing attention and are now thought to be key regulators of tumor initiation and progression. Of particular relevance to the work reviewed herein are the fibroblasts, which make up the major cell type within the microenvironment of most carcinomas. Due to their inherent heterogeneity, plasticity, and function, it is perhaps not surprising that fibroblasts are ideal modulators of normal and cancerous epithelium; however, these aspects also present challenges if we are to interrupt their tumor-supportive functions. Here, we review the current body of knowledge and the many questions that still remain about the special entity known as the cancer-associated fibroblast. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. (C) 2012 Published by Elsevier B.V. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3932378
- author
- Marsh, Timothy
; Pietras, Kristian
LU
and McAllister, Sandra S.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fibrosis, Cancer, Cancer-associated fibroblasts, Bone marrow cells, Heterogeneity
- in
- Biochimica et Biophysica Acta - Molecular Basis of Disease
- volume
- 1832
- issue
- 7
- pages
- 1070 - 1078
- publisher
- Elsevier
- external identifiers
-
- wos:000318887500025
- scopus:84877065511
- ISSN
- 0925-4439
- DOI
- 10.1016/j.bbadis2012.10.013
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental oncology (013031110)
- id
- 643461d9-3bca-404d-9356-92da34e5be21 (old id 3932378)
- date added to LUP
- 2016-04-01 13:48:03
- date last changed
- 2022-04-14 03:10:57
@article{643461d9-3bca-404d-9356-92da34e5be21,
abstract = {{Studies of epithelial cancers (i.e., carcinomas) traditionally focused on transformation of the epithelium (i.e., the cancer cells) and how aberrant signaling within the cancer cells modulates the surrounding tissue of origin. In more recent decades, the normal cells, blood vessels, molecules, and extracellular components that surround the tumor cells, collectively known as the "tumor microenvironment" or "stroma", have received increasing attention and are now thought to be key regulators of tumor initiation and progression. Of particular relevance to the work reviewed herein are the fibroblasts, which make up the major cell type within the microenvironment of most carcinomas. Due to their inherent heterogeneity, plasticity, and function, it is perhaps not surprising that fibroblasts are ideal modulators of normal and cancerous epithelium; however, these aspects also present challenges if we are to interrupt their tumor-supportive functions. Here, we review the current body of knowledge and the many questions that still remain about the special entity known as the cancer-associated fibroblast. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. (C) 2012 Published by Elsevier B.V.}},
author = {{Marsh, Timothy and Pietras, Kristian and McAllister, Sandra S.}},
issn = {{0925-4439}},
keywords = {{Fibrosis; Cancer; Cancer-associated fibroblasts; Bone marrow cells; Heterogeneity}},
language = {{eng}},
number = {{7}},
pages = {{1070--1078}},
publisher = {{Elsevier}},
series = {{Biochimica et Biophysica Acta - Molecular Basis of Disease}},
title = {{Fibroblasts as architects of cancer pathogenesis}},
url = {{https://lup.lub.lu.se/search/files/3597675/4178397.pdf}},
doi = {{10.1016/j.bbadis2012.10.013}},
volume = {{1832}},
year = {{2013}},
}