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Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate

Sliwa, Ewa; Dobrowolski, Piotr; Siwicki, Andrzej Krzysztof and Pierzynowski, Stefan LU (2007) In Bulletin of the Veterinary Institute in Puławy 51(2). p.297-301
Abstract
The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d... (More)
The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30(th) d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ceruloplasinin, lysozyme, piglets, alpha-ketoglutarate, total proteins
in
Bulletin of the Veterinary Institute in Puławy
volume
51
issue
2
pages
297 - 301
publisher
National Veterinary Research Institute
external identifiers
  • wos:000247794900022
ISSN
0042-4870
language
English
LU publication?
yes
id
bee1b167-3215-4337-a7ee-96fda0bfee7a (old id 645921)
date added to LUP
2008-01-03 08:24:07
date last changed
2016-04-16 04:44:22
@article{bee1b167-3215-4337-a7ee-96fda0bfee7a,
  abstract     = {The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30(th) d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets.},
  author       = {Sliwa, Ewa and Dobrowolski, Piotr and Siwicki, Andrzej Krzysztof and Pierzynowski, Stefan},
  issn         = {0042-4870},
  keyword      = {ceruloplasinin,lysozyme,piglets,alpha-ketoglutarate,total proteins},
  language     = {eng},
  number       = {2},
  pages        = {297--301},
  publisher    = {National Veterinary Research Institute},
  series       = {Bulletin of the Veterinary Institute in Puławy},
  title        = {Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate},
  volume       = {51},
  year         = {2007},
}