Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate
(2007) In Bulletin of the Veterinary Institute in Puławy 51(2). p.297-301- Abstract
- The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d... (More)
- The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30(th) d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/645921
- author
- Sliwa, Ewa ; Dobrowolski, Piotr ; Siwicki, Andrzej Krzysztof and Pierzynowski, Stefan LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ceruloplasinin, lysozyme, piglets, alpha-ketoglutarate, total proteins
- in
- Bulletin of the Veterinary Institute in Puławy
- volume
- 51
- issue
- 2
- pages
- 297 - 301
- publisher
- National Veterinary Research Institute
- external identifiers
-
- wos:000247794900022
- scopus:34547981542
- ISSN
- 0042-4870
- language
- English
- LU publication?
- yes
- id
- bee1b167-3215-4337-a7ee-96fda0bfee7a (old id 645921)
- date added to LUP
- 2016-04-01 16:41:47
- date last changed
- 2022-01-28 21:28:36
@article{bee1b167-3215-4337-a7ee-96fda0bfee7a,
abstract = {{The aim of this study was to establish the influence of alpha-ketoglutarate (AKG), administered to pregnant sows from the 91(SI) d of pregnancy to farrowing, and then to piglets from birth to the 30(th) d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14(th) and 30(th) d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30(th) d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets.}},
author = {{Sliwa, Ewa and Dobrowolski, Piotr and Siwicki, Andrzej Krzysztof and Pierzynowski, Stefan}},
issn = {{0042-4870}},
keywords = {{ceruloplasinin; lysozyme; piglets; alpha-ketoglutarate; total proteins}},
language = {{eng}},
number = {{2}},
pages = {{297--301}},
publisher = {{National Veterinary Research Institute}},
series = {{Bulletin of the Veterinary Institute in Puławy}},
title = {{Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate}},
volume = {{51}},
year = {{2007}},
}