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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Dalrymple, Annette; Wild, Edward J.; Joubert, Richard; Sathasivam, Kirupa; Bjorkqvist, Maria; Petersén, Åsa LU ; Jackson, Graham S.; Isaacs, Jeremy D.; Kristiansen, Mark and Bates, Gillian P., et al. (2007) In Journal of Proteome Research 6(7). p.2833-2840
Abstract
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
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Contribution to journal
publication status
published
subject
keywords
electrophoresis, 2D, proteomics, neuroinflammation, Huntington's disease, plasma, LC/MS/MS, MALDI-TOF, ELISA, biomarkers
in
Journal of Proteome Research
volume
6
issue
7
pages
2833 - 2840
publisher
The American Chemical Society
external identifiers
  • wos:000247792300042
  • scopus:34547167008
ISSN
1535-3893
DOI
10.1021/pr0700753
language
English
LU publication?
yes
id
02343b16-69cd-4e97-94a6-b3f1f76d3d39 (old id 646337)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17552550&dopt=Abstract
date added to LUP
2007-12-11 11:14:17
date last changed
2017-11-19 03:35:33
@article{02343b16-69cd-4e97-94a6-b3f1f76d3d39,
  abstract     = {Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.},
  author       = {Dalrymple, Annette and Wild, Edward J. and Joubert, Richard and Sathasivam, Kirupa and Bjorkqvist, Maria and Petersén, Åsa and Jackson, Graham S. and Isaacs, Jeremy D. and Kristiansen, Mark and Bates, Gillian P. and Leavitt, Blair R. and Keir, Geoff and Ward, Malcolm and Tabrizi, Sarah J.},
  issn         = {1535-3893},
  keyword      = {electrophoresis,2D,proteomics,neuroinflammation,Huntington's disease,plasma,LC/MS/MS,MALDI-TOF,ELISA,biomarkers},
  language     = {eng},
  number       = {7},
  pages        = {2833--2840},
  publisher    = {The American Chemical Society},
  series       = {Journal of Proteome Research},
  title        = {Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates},
  url          = {http://dx.doi.org/10.1021/pr0700753},
  volume       = {6},
  year         = {2007},
}