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Role of fibroblast growth factor 8 in growth and progression of hormonal cancer

Mattila, Mirjami A. and Härkönen, Pirkko LU (2007) In Cytokine & Growth Factor Reviews 18(3-4). p.257-266
Abstract
Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediated by paracrine and autocrine target molecules which include growth factors and growth factor receptors. During cancer progression the hormonal growth regulation is often lost or overcome by an inappropriate activation of growth factor signaling cascades. One of the growth factors which have been associated with the regulation of growth and progression of hormonal cancer is fibroblast growth factor 8 (FGF8) which has also been... (More)
Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediated by paracrine and autocrine target molecules which include growth factors and growth factor receptors. During cancer progression the hormonal growth regulation is often lost or overcome by an inappropriate activation of growth factor signaling cascades. One of the growth factors which have been associated with the regulation of growth and progression of hormonal cancer is fibroblast growth factor 8 (FGF8) which has also been recognized as an oncogene. FGF8 is widely expressed during embryonic development. It has been shown to mediate embryonic epithelial-mesenchymal transition and to have a crucial role in gastrulation and early organization and differentiation of midbrain/hindbrain, pharyngeal, cardiac, urogenital and limb structures. During adulthood FGF8 expression is much more restricted but in hormonal cancers it becomes frequently activated. High level of FGF8 expression in tumors is associated with a poor prognosis at least in prostate cancer. In experimental models FGF8 induces and facilitates prostate tumorigenesis and increases growth and angiogenesis of tumors. Several lines of evidence for autocrine and paracrine loops in the growth regulation of breast, prostate and ovarian cancer by FGF8 have been suggested. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
angiogenesis, proliferation, prostate cancer, FGF8, breast cancer
in
Cytokine & Growth Factor Reviews
volume
18
issue
3-4
pages
257 - 266
publisher
Elsevier
external identifiers
  • wos:000248074700006
  • scopus:34249990979
ISSN
1359-6101
DOI
10.1016/j.cytogfr.2007.04.010
language
English
LU publication?
yes
id
f94fdba3-c002-4eb9-a897-f878acf05692 (old id 647503)
date added to LUP
2007-12-13 16:46:49
date last changed
2017-10-22 03:46:08
@article{f94fdba3-c002-4eb9-a897-f878acf05692,
  abstract     = {Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediated by paracrine and autocrine target molecules which include growth factors and growth factor receptors. During cancer progression the hormonal growth regulation is often lost or overcome by an inappropriate activation of growth factor signaling cascades. One of the growth factors which have been associated with the regulation of growth and progression of hormonal cancer is fibroblast growth factor 8 (FGF8) which has also been recognized as an oncogene. FGF8 is widely expressed during embryonic development. It has been shown to mediate embryonic epithelial-mesenchymal transition and to have a crucial role in gastrulation and early organization and differentiation of midbrain/hindbrain, pharyngeal, cardiac, urogenital and limb structures. During adulthood FGF8 expression is much more restricted but in hormonal cancers it becomes frequently activated. High level of FGF8 expression in tumors is associated with a poor prognosis at least in prostate cancer. In experimental models FGF8 induces and facilitates prostate tumorigenesis and increases growth and angiogenesis of tumors. Several lines of evidence for autocrine and paracrine loops in the growth regulation of breast, prostate and ovarian cancer by FGF8 have been suggested.},
  author       = {Mattila, Mirjami A. and Härkönen, Pirkko},
  issn         = {1359-6101},
  keyword      = {angiogenesis,proliferation,prostate cancer,FGF8,breast cancer},
  language     = {eng},
  number       = {3-4},
  pages        = {257--266},
  publisher    = {Elsevier},
  series       = {Cytokine & Growth Factor Reviews},
  title        = {Role of fibroblast growth factor 8 in growth and progression of hormonal cancer},
  url          = {http://dx.doi.org/10.1016/j.cytogfr.2007.04.010},
  volume       = {18},
  year         = {2007},
}