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Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study

Filip, Rafal S.; Pierzynowski, Stefan LU ; Lindegard, Birger; Wernerman, Jan; Haratym-Maj, Agnieszka and Podgurniak, Malgorzata (2007) In International Journal for Vitamin and Nutrition Research 77(2). p.89-97
Abstract
Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The... (More)
Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
osteocalcin, collagen, alpha-ketoglutarate, C-terminal cross-linking telopeptide of type I, osteopenia, bone mineral density (BDM)
in
International Journal for Vitamin and Nutrition Research
volume
77
issue
2
pages
89 - 97
publisher
Verlag Hans Huber
external identifiers
  • wos:000247546300003
  • scopus:34250891909
ISSN
0300-9831
DOI
10.1024/0300-9831.77.2.89
language
English
LU publication?
yes
id
b5410b14-f340-4a9f-8972-160d589afa54 (old id 647746)
date added to LUP
2007-12-11 20:57:53
date last changed
2017-02-12 04:07:46
@article{b5410b14-f340-4a9f-8972-160d589afa54,
  abstract     = {Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated.},
  author       = {Filip, Rafal S. and Pierzynowski, Stefan and Lindegard, Birger and Wernerman, Jan and Haratym-Maj, Agnieszka and Podgurniak, Malgorzata},
  issn         = {0300-9831},
  keyword      = {osteocalcin,collagen,alpha-ketoglutarate,C-terminal cross-linking telopeptide of type I,osteopenia,bone mineral density (BDM)},
  language     = {eng},
  number       = {2},
  pages        = {89--97},
  publisher    = {Verlag Hans Huber},
  series       = {International Journal for Vitamin and Nutrition Research},
  title        = {Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study},
  url          = {http://dx.doi.org/10.1024/0300-9831.77.2.89},
  volume       = {77},
  year         = {2007},
}