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HPV type-specific risks of high-grade CIN during 4 years of follow-up: A population-based prospective study

Naucler, Pontus LU ; Ryd, W.; Tornberg, S.; Strand, A.; Wadell, G.; Hansson, Bengt-Göran LU ; Rylander, E. and Dillner, Joakim LU (2007) In British Journal of Cancer 97(1). p.129-132
Abstract
We followed a population-based cohort of 5696 women, 32 - 38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 + development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 + cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2 + than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2 +. In summary, the different HPV types found in cervical cancer show distinctly different CIN2... (More)
We followed a population-based cohort of 5696 women, 32 - 38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 + development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 + cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2 + than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2 +. In summary, the different HPV types found in cervical cancer show distinctly different CIN2 + risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
attributable proportion, papillomavirus, cervical cancer, screening, cohort studies
in
British Journal of Cancer
volume
97
issue
1
pages
129 - 132
publisher
Nature Publishing Group
external identifiers
  • wos:000247597200020
  • scopus:34347357674
ISSN
1532-1827
DOI
10.1038/sj.bjc.6603843
language
English
LU publication?
yes
id
0ad6fb67-7751-464e-a6c3-e24ba2e856e0 (old id 647841)
date added to LUP
2007-12-04 15:15:40
date last changed
2017-01-01 05:07:52
@article{0ad6fb67-7751-464e-a6c3-e24ba2e856e0,
  abstract     = {We followed a population-based cohort of 5696 women, 32 - 38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 + development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 + cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2 + than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2 +. In summary, the different HPV types found in cervical cancer show distinctly different CIN2 + risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33.},
  author       = {Naucler, Pontus and Ryd, W. and Tornberg, S. and Strand, A. and Wadell, G. and Hansson, Bengt-Göran and Rylander, E. and Dillner, Joakim},
  issn         = {1532-1827},
  keyword      = {attributable proportion,papillomavirus,cervical cancer,screening,cohort studies},
  language     = {eng},
  number       = {1},
  pages        = {129--132},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {HPV type-specific risks of high-grade CIN during 4 years of follow-up: A population-based prospective study},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6603843},
  volume       = {97},
  year         = {2007},
}