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Continuous full filling capillary electrochromatography: Nanoparticle synthesis and evaluation

Spégel, Peter LU ; Viberg, Peter LU ; Carlstedt, Jonas LU ; Petersson, Patrik and Jornten-Karlsson, Magnus (2007) In Journal of Chromatography A 1154(1-2). p.379-385
Abstract
Reversed phase continuous full filling capillary electrochromatography with electrospray ionisation mass spectrometric detection was performed with highly sulphated poly [styrene-co-(lauryl methacrylate)-co-(divinylbenzene)] nanoparticles. The nanoparticles that contained a hydrophobic core and a hydrophilic surface were prepared in a one step synthesis using soap free emulsion polymerisation. By changing the concentration of monomers, the polymerisation temperature, and the polarity of the dispersive phase, the size of the nanoparticles could be controlled. With the optimised conditions, nanoparticles with an average size of 157 nm were obtained. These nanoparticles were dispersed in the background electrolyte and used for reversed phase... (More)
Reversed phase continuous full filling capillary electrochromatography with electrospray ionisation mass spectrometric detection was performed with highly sulphated poly [styrene-co-(lauryl methacrylate)-co-(divinylbenzene)] nanoparticles. The nanoparticles that contained a hydrophobic core and a hydrophilic surface were prepared in a one step synthesis using soap free emulsion polymerisation. By changing the concentration of monomers, the polymerisation temperature, and the polarity of the dispersive phase, the size of the nanoparticles could be controlled. With the optimised conditions, nanoparticles with an average size of 157 nm were obtained. These nanoparticles were dispersed in the background electrolyte and used for reversed phase continuous full filling. An orthogonal electrospray ionisation interface was used to separate the eluting nanoparticles from the eluting analytes prior to mass spectrometry detection. Compared to previous studies on reversed phase continuous full filling, the retention, the separation efficiency, and the resolution of a homologous series of dialkyl phthalates were greatly improved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
continuous full filling, electrospray ionisation, orthogonal, capillary electrochromatography, mass spectrometry, pseudostationary, phase, reversed phase
in
Journal of Chromatography A
volume
1154
issue
1-2
pages
379 - 385
publisher
Elsevier
external identifiers
  • wos:000247419300044
  • scopus:34249690201
ISSN
0021-9673
DOI
10.1016/j.chroma.2007.02.092
language
English
LU publication?
yes
id
7f6274d2-59e3-4705-a96e-f4bb0009f833 (old id 648052)
date added to LUP
2007-12-19 09:36:48
date last changed
2017-10-22 04:49:10
@article{7f6274d2-59e3-4705-a96e-f4bb0009f833,
  abstract     = {Reversed phase continuous full filling capillary electrochromatography with electrospray ionisation mass spectrometric detection was performed with highly sulphated poly [styrene-co-(lauryl methacrylate)-co-(divinylbenzene)] nanoparticles. The nanoparticles that contained a hydrophobic core and a hydrophilic surface were prepared in a one step synthesis using soap free emulsion polymerisation. By changing the concentration of monomers, the polymerisation temperature, and the polarity of the dispersive phase, the size of the nanoparticles could be controlled. With the optimised conditions, nanoparticles with an average size of 157 nm were obtained. These nanoparticles were dispersed in the background electrolyte and used for reversed phase continuous full filling. An orthogonal electrospray ionisation interface was used to separate the eluting nanoparticles from the eluting analytes prior to mass spectrometry detection. Compared to previous studies on reversed phase continuous full filling, the retention, the separation efficiency, and the resolution of a homologous series of dialkyl phthalates were greatly improved.},
  author       = {Spégel, Peter and Viberg, Peter and Carlstedt, Jonas and Petersson, Patrik and Jornten-Karlsson, Magnus},
  issn         = {0021-9673},
  keyword      = {continuous full filling,electrospray ionisation,orthogonal,capillary electrochromatography,mass spectrometry,pseudostationary,phase,reversed phase},
  language     = {eng},
  number       = {1-2},
  pages        = {379--385},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {Continuous full filling capillary electrochromatography: Nanoparticle synthesis and evaluation},
  url          = {http://dx.doi.org/10.1016/j.chroma.2007.02.092},
  volume       = {1154},
  year         = {2007},
}