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Lack of very strong association between pre-treatment fibrinogen and PAI-1 with long-term mortality after coronary bypass surgery

Sjoland, Helen; Tengborn, Lilian LU ; Stensdotter, Lillemor and Herlitz, Johan (2007) In Cardiology 108(2). p.82-89
Abstract
Aim: To explore the association between the coagulation protein fibrinogen and the fibrinolytic biomarker plasminogen activator inhibitor-1 ( PAI- 1) and the long- term mortality after coronary artery bypass grafting ( CABG). Patients and Methods: In 729 patients undergoing CABG at Sahlgrenska University Hospital, a blood sample for fibrinogen and PAI-1 was collected prior to the procedure. Patients were followed for 10 years. Results: Among patients with high levels of fibrinogen (> 3.6 g/ l; median), the 10-year mortality was 32.3 vs. 20.7% among patients with fibrinogen levels below the median ( p = 0.0005). However, patients with higher levels of fibrinogen were older and had an adverse risk factor pattern. When adjusting for these... (More)
Aim: To explore the association between the coagulation protein fibrinogen and the fibrinolytic biomarker plasminogen activator inhibitor-1 ( PAI- 1) and the long- term mortality after coronary artery bypass grafting ( CABG). Patients and Methods: In 729 patients undergoing CABG at Sahlgrenska University Hospital, a blood sample for fibrinogen and PAI-1 was collected prior to the procedure. Patients were followed for 10 years. Results: Among patients with high levels of fibrinogen (> 3.6 g/ l; median), the 10-year mortality was 32.3 vs. 20.7% among patients with fibrinogen levels below the median ( p = 0.0005). However, patients with higher levels of fibrinogen were older and had an adverse risk factor pattern. When adjusting for these differences, pre- operative fibrinogen levels did not clearly appear as an independent predictor of long- term mortality. The 10- year mortality was similar in patients with high ( 25.3%) and low ( 26.5%) levels of PAI-1. Conclusion: Our results do not suggest that fibrinogen and PAI- 1, when evaluated prior to the operative procedure, arestrongly associated with increased mortality in the longterm after CABG, when other co-morbidity factors are simultaneously considered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, fibrinogen, coronary artery surgery, plasminogen activator, inhibitor
in
Cardiology
volume
108
issue
2
pages
82 - 89
publisher
Karger
external identifiers
  • wos:000247435400003
  • scopus:34548096986
ISSN
1421-9751
DOI
10.1159/000095935
language
English
LU publication?
yes
id
e37b5d81-8a2c-4030-aea1-484e36a86606 (old id 648152)
date added to LUP
2007-12-14 16:18:21
date last changed
2017-01-01 04:44:52
@article{e37b5d81-8a2c-4030-aea1-484e36a86606,
  abstract     = {Aim: To explore the association between the coagulation protein fibrinogen and the fibrinolytic biomarker plasminogen activator inhibitor-1 ( PAI- 1) and the long- term mortality after coronary artery bypass grafting ( CABG). Patients and Methods: In 729 patients undergoing CABG at Sahlgrenska University Hospital, a blood sample for fibrinogen and PAI-1 was collected prior to the procedure. Patients were followed for 10 years. Results: Among patients with high levels of fibrinogen (> 3.6 g/ l; median), the 10-year mortality was 32.3 vs. 20.7% among patients with fibrinogen levels below the median ( p = 0.0005). However, patients with higher levels of fibrinogen were older and had an adverse risk factor pattern. When adjusting for these differences, pre- operative fibrinogen levels did not clearly appear as an independent predictor of long- term mortality. The 10- year mortality was similar in patients with high ( 25.3%) and low ( 26.5%) levels of PAI-1. Conclusion: Our results do not suggest that fibrinogen and PAI- 1, when evaluated prior to the operative procedure, arestrongly associated with increased mortality in the longterm after CABG, when other co-morbidity factors are simultaneously considered.},
  author       = {Sjoland, Helen and Tengborn, Lilian and Stensdotter, Lillemor and Herlitz, Johan},
  issn         = {1421-9751},
  keyword      = {prognosis,fibrinogen,coronary artery surgery,plasminogen activator,inhibitor},
  language     = {eng},
  number       = {2},
  pages        = {82--89},
  publisher    = {Karger},
  series       = {Cardiology},
  title        = {Lack of very strong association between pre-treatment fibrinogen and PAI-1 with long-term mortality after coronary bypass surgery},
  url          = {http://dx.doi.org/10.1159/000095935},
  volume       = {108},
  year         = {2007},
}