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An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

Brownbill, Paul; Chernyavsky, Igor; Bottalico, Barbara LU ; Desoye, Gernot; Hansson, Stefan LU ; Kenna, Gerry; Knudsen, Lisbeth E.; Markert, Udo R.; Powles-Glover, Nicola and Schneider, Henning, et al. (2016) In Reproductive Toxicology 64. p.191-202
Abstract

The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed... (More)

The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.

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publication status
published
subject
keywords
3Rs, Human placenta, PlaNet, Reproductive toxicology testing
in
Reproductive Toxicology
volume
64
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:84977669433
  • wos:000381956700017
ISSN
0890-6238
DOI
10.1016/j.reprotox.2016.06.006
language
English
LU publication?
yes
id
64bc366a-3195-4387-a4dd-14ffc0e04c3a
date added to LUP
2016-12-20 07:34:36
date last changed
2017-11-19 04:36:03
@article{64bc366a-3195-4387-a4dd-14ffc0e04c3a,
  abstract     = {<p>The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.</p>},
  author       = {Brownbill, Paul and Chernyavsky, Igor and Bottalico, Barbara and Desoye, Gernot and Hansson, Stefan and Kenna, Gerry and Knudsen, Lisbeth E. and Markert, Udo R. and Powles-Glover, Nicola and Schneider, Henning and Leach, Lopa},
  issn         = {0890-6238},
  keyword      = {3Rs,Human placenta,PlaNet,Reproductive toxicology testing},
  language     = {eng},
  month        = {09},
  pages        = {191--202},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2016.06.006},
  volume       = {64},
  year         = {2016},
}