Interpretation threshold values for patient-reported outcomes in patients participating in a digitally delivered first-line treatment program for hip or knee osteoarthritis
(2023) In Osteoarthritis and Cartilage Open 5(3).- Abstract
- Objective
Establish proportions of patients reporting important improvement, acceptable symptoms and treatment failure and define interpretation threshold values for pain, patient-reported function and quality-of-life after participating in digital first-line treatment including education and exercise for hip and knee osteoarthritis (OA).
Methods
Observational study. Responses to the pain Numeric Rating Scale (NRS, 0-10 best to worst), Knee injury and Osteoarthritis Outcome Score 12 (KOOS-12) and Hip disability and Osteoarthritis Outcome Score 12 (HOOS-12, both 0-100 worst to best) were obtained for 4383 (2987) and 20341 (1264) participants with knee (hip) OA at 3 and 12 months post intervention.. Threshold values for... (More) - Objective
Establish proportions of patients reporting important improvement, acceptable symptoms and treatment failure and define interpretation threshold values for pain, patient-reported function and quality-of-life after participating in digital first-line treatment including education and exercise for hip and knee osteoarthritis (OA).
Methods
Observational study. Responses to the pain Numeric Rating Scale (NRS, 0-10 best to worst), Knee injury and Osteoarthritis Outcome Score 12 (KOOS-12) and Hip disability and Osteoarthritis Outcome Score 12 (HOOS-12, both 0-100 worst to best) were obtained for 4383 (2987) and 20341 (1264) participants with knee (hip) OA at 3 and 12 months post intervention.. Threshold values for Minimal Important Change (MIC), Patient Acceptable Symptom State (PASS) and Treatment Failure (TF) were estimated using anchor-based predictive modeling.
Results
70–85% reported an important improvement in pain, function and quality of life after 3 and 12 months follow-up. 42% (3 months) and 51% (12 months) considered their current state as satisfactory, whereas 2-4% considered treatment failed. MIC values were -1 (NRS) and 0-4 (KOOS/HOOS-12) across follow-ups and joint affected. PASS threshold value for NRS was 3, and 53–73 for the KOOS/HOOS-12 subscales Corresponding values for TF were 5 (NRS) and 34–55 (KOOS/HOOS-12). Patients with more severe pain at baseline had higher MIC scores and accepted poorer outcomes at follow-ups.
Conclusion
Threshold estimates aid in the interpretation of outcomes after first-line OA interventions assessed with NRS Pain and KOOS/HOOS-12. Baseline pain severity is important to consider when interpreting threshold values after first-line interventions in these patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/64bf9403-05da-426d-bc7a-bd0c31ac455c
- author
- Cronström, Anna LU ; Ingelsrud, Lina H. ; Nero, Håkan LU ; Lohmander, L Stefan LU ; Ignjatovic, Majda Misini LU ; Dahlberg, Leif E. LU and Kiadaliri, Ali LU
- organization
-
- Sport Sciences (research group)
- Lund OsteoArthritis Division - From molecule to clinical implementation (research group)
- EpiHealth: Epidemiology for Health
- Lund OsteoArthritis Division - Molecular marker research group (research group)
- Lund OsteoArthritis Division - Clinical Epidemiology Unit (research group)
- LU Profile Area: Proactive Ageing
- publishing date
- 2023-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage Open
- volume
- 5
- issue
- 3
- article number
- 100375
- publisher
- Elsevier
- external identifiers
-
- scopus:85162510328
- pmid:37275788
- ISSN
- 2665-9131
- DOI
- 10.1016/j.ocarto.2023.100375
- project
- Digital education and physical therapy for people with musculoskeletal pain
- language
- English
- LU publication?
- yes
- id
- 64bf9403-05da-426d-bc7a-bd0c31ac455c
- date added to LUP
- 2023-05-24 17:06:53
- date last changed
- 2023-11-22 18:47:56
@article{64bf9403-05da-426d-bc7a-bd0c31ac455c, abstract = {{Objective<br/>Establish proportions of patients reporting important improvement, acceptable symptoms and treatment failure and define interpretation threshold values for pain, patient-reported function and quality-of-life after participating in digital first-line treatment including education and exercise for hip and knee osteoarthritis (OA).<br/><br/>Methods<br/>Observational study. Responses to the pain Numeric Rating Scale (NRS, 0-10 best to worst), Knee injury and Osteoarthritis Outcome Score 12 (KOOS-12) and Hip disability and Osteoarthritis Outcome Score 12 (HOOS-12, both 0-100 worst to best) were obtained for 4383 (2987) and 20341 (1264) participants with knee (hip) OA at 3 and 12 months post intervention.. Threshold values for Minimal Important Change (MIC), Patient Acceptable Symptom State (PASS) and Treatment Failure (TF) were estimated using anchor-based predictive modeling.<br/><br/>Results<br/>70–85% reported an important improvement in pain, function and quality of life after 3 and 12 months follow-up. 42% (3 months) and 51% (12 months) considered their current state as satisfactory, whereas 2-4% considered treatment failed. MIC values were -1 (NRS) and 0-4 (KOOS/HOOS-12) across follow-ups and joint affected. PASS threshold value for NRS was 3, and 53–73 for the KOOS/HOOS-12 subscales Corresponding values for TF were 5 (NRS) and 34–55 (KOOS/HOOS-12). Patients with more severe pain at baseline had higher MIC scores and accepted poorer outcomes at follow-ups.<br/><br/>Conclusion<br/>Threshold estimates aid in the interpretation of outcomes after first-line OA interventions assessed with NRS Pain and KOOS/HOOS-12. Baseline pain severity is important to consider when interpreting threshold values after first-line interventions in these patients.}}, author = {{Cronström, Anna and Ingelsrud, Lina H. and Nero, Håkan and Lohmander, L Stefan and Ignjatovic, Majda Misini and Dahlberg, Leif E. and Kiadaliri, Ali}}, issn = {{2665-9131}}, language = {{eng}}, month = {{05}}, number = {{3}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage Open}}, title = {{Interpretation threshold values for patient-reported outcomes in patients participating in a digitally delivered first-line treatment program for hip or knee osteoarthritis}}, url = {{http://dx.doi.org/10.1016/j.ocarto.2023.100375}}, doi = {{10.1016/j.ocarto.2023.100375}}, volume = {{5}}, year = {{2023}}, }