Short-term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine
Ohlsson, Lena LU ; Isaxon, Christina LU ; Wrighton, Sebastian LU
; El Ouahidi, Wissal
; Fornell, Lisa
; Uller, Lena
LU
; Ansar, Saema
LU
and Voss, Ulrikke
LU
(2022)
In Physiological Reports
10(7).
- Abstract
Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5-contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short- or long-term exposure to urban PM2.5. Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM2.5/m3 for 8 h (short term) or 1.8 mg PM2.5/m3 for 3 h/day, 5 days/week for 8 weeks (long-term)... (More)
Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5-contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short- or long-term exposure to urban PM2.5. Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM2.5/m3 for 8 h (short term) or 1.8 mg PM2.5/m3 for 3 h/day, 5 days/week for 8 weeks (long-term) with controls run in parallel. Samples were taken from three regions of the small intestine as well as the colon. Results showed that short-term exposure to PM2.5 induces mucosal lesions and reduces IL1β levels in the small intestine but not colon. No significant changes were observed after long-term exposure, suggesting the presence of intestinal adaptation to environmental stressors in the PM2.5. To our knowledge, this is the first study to systematically characterize regional effects along the intestine.
(Less)
- author
- Ohlsson, Lena
LU
; Isaxon, Christina
LU
; Wrighton, Sebastian
LU
; El Ouahidi, Wissal
; Fornell, Lisa
; Uller, Lena
LU
; Ansar, Saema
LU
and Voss, Ulrikke
LU
- organization
-
- Experimental Vascular Research (research group)
- Ergonomics and Aerosol Technology
- NanoLund: Centre for Nanoscience
- Quantitative immunobiology (research group)
- Infection Medicine (BMC)
- epIgG (research group)
- Respiratory Immunopharmacology (research group)
- Neurosurgery
- Applied Neurovascular Research (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2022-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- environmental, gastrointestinal, inflammation, physiology, toxicology, urban air pollution
- in
- Physiological Reports
- volume
- 10
- issue
- 7
- article number
- e15249
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:35416410
- scopus:85128153654
- ISSN
- 2051-817X
- DOI
- 10.14814/phy2.15249
- language
- English
- LU publication?
- yes
- id
- 64c154b5-0fbc-4d54-b6e0-6e8d51475b08
- date added to LUP
- 2022-07-05 13:44:26
- date last changed
- 2024-04-16 14:33:10
@article{64c154b5-0fbc-4d54-b6e0-6e8d51475b08,
abstract = {{<p>Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM<sub>2.5</sub>) negatively impacts human health. Airways constitute a primary route of exposure but PM<sub>2.5</sub>-contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short- or long-term exposure to urban PM<sub>2.5</sub>. Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM<sub>2.5</sub>/m<sup>3</sup> for 8 h (short term) or 1.8 mg PM<sub>2.5</sub>/m<sup>3</sup> for 3 h/day, 5 days/week for 8 weeks (long-term) with controls run in parallel. Samples were taken from three regions of the small intestine as well as the colon. Results showed that short-term exposure to PM<sub>2.5</sub> induces mucosal lesions and reduces IL1β levels in the small intestine but not colon. No significant changes were observed after long-term exposure, suggesting the presence of intestinal adaptation to environmental stressors in the PM<sub>2.5</sub>. To our knowledge, this is the first study to systematically characterize regional effects along the intestine.</p>}},
author = {{Ohlsson, Lena and Isaxon, Christina and Wrighton, Sebastian and El Ouahidi, Wissal and Fornell, Lisa and Uller, Lena and Ansar, Saema and Voss, Ulrikke}},
issn = {{2051-817X}},
keywords = {{environmental; gastrointestinal; inflammation; physiology; toxicology; urban air pollution}},
language = {{eng}},
number = {{7}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Physiological Reports}},
title = {{Short-term exposure to urban PM<sub>2.5</sub> particles induces histopathological and inflammatory changes in the rat small intestine}},
url = {{http://dx.doi.org/10.14814/phy2.15249}},
doi = {{10.14814/phy2.15249}},
volume = {{10}},
year = {{2022}},
}