Risk of haemorrhagic and ischaemic stroke in patients with cancer: A nationwide follow-up study from Sweden.
Zöller, Bengt LU
; Ji, Jianguang
LU
; Sundquist, Jan
LU
and Sundquist, Kristina
LU
(2012)
In European Journal of Cancer
48(12).
p.1875-1883
- Abstract
- BACKGROUND: Stroke is common in cancer patients, but risk estimates for different cancer sites/types have not been determined. The aim of this nationwide study was to examine whether there is an association between cancer and first hospitalisation for haemorrhagic or ischaemic stroke. METHODS: All 820,491 individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for haemorrhagic or ischaemic stroke. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for haemorrhagic and ischaemic strokes were calculated. RESULTS: Overall risk of haemorrhagic stroke and ischaemic stroke during the first 6months after... (More)
- BACKGROUND: Stroke is common in cancer patients, but risk estimates for different cancer sites/types have not been determined. The aim of this nationwide study was to examine whether there is an association between cancer and first hospitalisation for haemorrhagic or ischaemic stroke. METHODS: All 820,491 individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for haemorrhagic or ischaemic stroke. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for haemorrhagic and ischaemic strokes were calculated. RESULTS: Overall risk of haemorrhagic stroke and ischaemic stroke during the first 6months after diagnosis of cancer was 2.2 (95% confidence interval (CI)=2.0-2.3) and 1.6 (CI=1.5-1.6), respectively. For 18 and 20 of the 34 cancers studied, respectively, risk of haemorrhagic and ischaemic strokes was increased. Overall stroke risk decreased rapidly, but remained elevated, even 10+years after diagnosis of cancer 1.2 (CI=1.1-1.3) for haemorrhagic stroke and 1.1 (CI=1.1-1.2) for ischaemic stroke. The risk of stroke was highest during the first 6months after diagnosis of cancer of the nervous system (29 (CI=25-34) for haemorrhagic stroke and 4.1 (CI=3.4-4.8) for ischaemic stroke)) or leukaemia (13 (CI=10-16) for haemorrhagic stroke and 3.0 (CI=2.5-3.7) for ischaemic stroke)). Metastasis was associated with an increased risk of haemorrhagic stroke 2.2 (CI=1.8-2.7) and ischaemic stroke 1.5 (CI=1.3-1.7). INTERPRETATION: Several cancer sites/types are associated with an increased risk of haemorrhagic and ischaemic strokes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2367436
- author
- Zöller, Bengt
LU
; Ji, Jianguang
LU
; Sundquist, Jan
LU
and Sundquist, Kristina
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cancer
- volume
- 48
- issue
- 12
- pages
- 1875 - 1883
- publisher
- Elsevier
- external identifiers
-
- wos:000306611200016
- pmid:22296948
- scopus:84864149732
- pmid:22296948
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2012.01.005
- language
- English
- LU publication?
- yes
- id
- 64d1771a-5ad7-49f4-aa9c-e273c1e95fa3 (old id 2367436)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22296948?dopt=Abstract
- date added to LUP
- 2016-04-04 07:30:53
- date last changed
- 2022-03-23 01:05:02
@article{64d1771a-5ad7-49f4-aa9c-e273c1e95fa3,
abstract = {{BACKGROUND: Stroke is common in cancer patients, but risk estimates for different cancer sites/types have not been determined. The aim of this nationwide study was to examine whether there is an association between cancer and first hospitalisation for haemorrhagic or ischaemic stroke. METHODS: All 820,491 individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for haemorrhagic or ischaemic stroke. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for haemorrhagic and ischaemic strokes were calculated. RESULTS: Overall risk of haemorrhagic stroke and ischaemic stroke during the first 6months after diagnosis of cancer was 2.2 (95% confidence interval (CI)=2.0-2.3) and 1.6 (CI=1.5-1.6), respectively. For 18 and 20 of the 34 cancers studied, respectively, risk of haemorrhagic and ischaemic strokes was increased. Overall stroke risk decreased rapidly, but remained elevated, even 10+years after diagnosis of cancer 1.2 (CI=1.1-1.3) for haemorrhagic stroke and 1.1 (CI=1.1-1.2) for ischaemic stroke. The risk of stroke was highest during the first 6months after diagnosis of cancer of the nervous system (29 (CI=25-34) for haemorrhagic stroke and 4.1 (CI=3.4-4.8) for ischaemic stroke)) or leukaemia (13 (CI=10-16) for haemorrhagic stroke and 3.0 (CI=2.5-3.7) for ischaemic stroke)). Metastasis was associated with an increased risk of haemorrhagic stroke 2.2 (CI=1.8-2.7) and ischaemic stroke 1.5 (CI=1.3-1.7). INTERPRETATION: Several cancer sites/types are associated with an increased risk of haemorrhagic and ischaemic strokes.}},
author = {{Zöller, Bengt and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1879-0852}},
language = {{eng}},
number = {{12}},
pages = {{1875--1883}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Risk of haemorrhagic and ischaemic stroke in patients with cancer: A nationwide follow-up study from Sweden.}},
url = {{http://dx.doi.org/10.1016/j.ejca.2012.01.005}},
doi = {{10.1016/j.ejca.2012.01.005}},
volume = {{48}},
year = {{2012}},
}